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"Elastic fibers and the mechanics of maturing arteries"
The presentation entitled, Elastic fibers and the mechanics of maturing arteries, is a more in-depth version of her presentation in the "Vascular Mechanics" session at Vascular Biology 2017 (Monterey, CA; October 15-19, 2017).
Elasticity of the large arteries is determined by the amount and quality of elastic fibers in the wall. Elastic fibers are composed of over 20 different proteins and the contribution of different proteins to arterial wall elasticity is largely unknown. We will present data on how arterial wall elasticity is affected by the loss of specific elastic fiber proteins in newborn and maturing mouse aorta and speculate on how these mechanical changes may lead to pathological remodeling in development and disease.
Much of this presentation will refer to her article in the Journal of Biomechanics, "Crosslinked elastic fibers are necessary for low energy loss in the ascending aorta" (2017 Aug 16;61:199-207. doi: 10.1016/j.jbiomech.2017.07.011. Epub 2017 Jul 25). Here is a link to the abstract of the article. If you have a subscription to the Journal of Biomechanics, you will have access to the full text.
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