Ex-vivo Muscle Physiological Studies
4-Channel high throughput MyoDYNAMIC Muscle Strip System with the capacity to perform isometric, eccentric, and concentric muscle contraction studies under a range of conditions.
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The MyoDynamics Muscle Strip System - 840MD represents a state-of-the-art 4-channel muscle strip system for intact muscle or muscle strips of up to 30 mm in length. The easy-to-use system allows the muscle physiologist to perform isometric, eccentric, and concentric contractions protocols performed by the build-in motors in a precise manner under a range of conditions, including electric field stimulation.
The system allows for four separate baths to run simultaneously and independently from each other. The system gives the flexibility to program each bath individually and initiate ad stop protocols independently from the other baths. Each muscle bath unit, made of aluminum, features a stainless steel chamber. The tissue mounting supports are positioned in the chamber, with one side attached to the force transducer and the other to a combination manual positioner screw and a motorized micropositioner. The manual positioner allows the accurate preload/base tension setting, while the motorized micropositioner permits the user to stretch (Eccentric)/relax (Concentric) the muscle according to user-defined settings. The sensitive force transducers provide measurements of contractile forces. Mounted tissue can be stretched and relaxed, defined by the user with a minimum distance of 10µm up to 11mm and a maximum speed of 11mm/sec. Stimulation electrodes built into the chamber cover (optional - various types) can activate the muscle via field stimulation from the DMT Stimulator. The 840MD has input and output trigger functions to activate the build-in motors by the DMT stimulator or visa versa. This system is well suited for studies involving muscle reactivity and fatigue experiment connected to neuromuscular disorders such as muscular dystrophy, metabolic, ataxia, and myofibrillar myopathies. Multiple units can be arranged side-by-side to facilitate high-throughput screening, such as drug testing or experiments requiring the separation of muscle preparations in individual baths. |
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*1 2-Years of Warranty included in purchase |
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Electrophysiological Studies -
General Protocol Types; # Dystrophic/mechanome affected muscles # General physiological examination of diseased and healthy muscles subjected to an intervention # Metabolic affected muscles – Glycolysis /glycogen decomposition # Metabolic affected muscles – Fatty acid conversion # Ion channel defects – force affected # Ion channel defects – indirect force affected # Myofibrillary myopathies |
Provided by courtesy of
Dr. Thomas Krag, Copenhagen Neuromuscular Center |
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Muscle Strip Chamber# Eccentric and concentric contractions # Control and measurement of length and isometric force # Direct or field stimulation # Up to 30mm muscle strip length # Acid resistens stainless steel chambers # Ideal for muscle reactivity and fatigue testing. |
Interface Unit# Integrated heating, gassing, & drainage # Selectable force range (mN) # Intregreted calibration procedure # Intuitive touch-screen interface menus # Compact design / small foot |
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