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Examine Functional Responses & Vascular
​Reactivity of Small Arteries

The range of applications is countless within isometric contraction and dilatation of smaller arteries, larger vessels such as the carotid artery and aorta, trachea, intestine, bladder, and many more...
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Shape Divider - Style triangle
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High Quality

Ideal for work requiring high throughput
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Thoughtful Design

Small Vessel Myograph & Traditional Organ Bath
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Latest Technology

Direct data streaming to LabChart by ADInstruments
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User Friendly

Reliable, flexible & trusted
The Multi Myograph System - model 620M is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in-vitro studies of vascular structure and function. The range of applications is countless within isometric contraction and dilatation of smaller arteries, larger vessels such as the carotid artery and aorta, trachea, intestine, bladder, and many more. 

Multiple 620M units, especially in combination with the Automatic Buffer Filler System - 625FS, can be conveniently arranged side-by-side. This makes the Multi Myograph 620M an ideal system for work requiring a higher throughput, such as drug screening, concentration responses, or experiments where individual testing of vessels in separate baths is necessary. 

Each individual myograph chamber, made of aluminum, has a centrally located stainless steel chamber. The tissue supports (jaws or pins) are then positioned in the chamber, where one side is attached to the force transducer, and the other side is attached to a micrometer. ​Each unit has individually controlled gas inflow and suction. Heating and connections for vacuum and gassing are in the myograph interface, permitting the preparations in all four chambers to be kept under physiological conditions (37°C and bubbled with a gas mixture of your choice). The interface in the Multi Wire Myograph System also houses all the electronics, and microprocessor for calibration, the circuitry for analog outputs, and a USB port for digital data acquisition using LabChart by ADInstruments and the DMT device enabler. 

Following mounting and equilibration, passive length-tension relationships for the vessels are determined using a normalization procedure. This ensures reproducibility amongst the segments and between experiments. During actual experiments, the circumference of the vessel is kept constant. Compounds can be added directly to the chamber, and the vessel contractility and reactivity are measured under isometric conditions.

This Multi Myograph System is highly suited for pharmacological investigations and vascular physiology of vessel reactivity. ​

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I’m stunned at how easy it is to mount vessels, put them in the chambers, and make sure that we control the variables that we need to when doing experiments. 
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Dr. Stephanie Watts

Professor in Pharmacology & Toxicology
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Michigan State University

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Chamber Unit

​
# Versatile function - myograph & organ bath in one
​# Acid resistent stainless steel chamber (avoid lipids/compounds sticking)
​# Ring-mounted segments >30µm / <10mm
# Low chamber volume
# ​XYZ adjustments for accurate alingment of segment
​​Interface Unit​

​# Integrated heating, gassing, & drainage
​# Direct data streaming
# Selectable force range (mN)
# Intregreted calibration procedure
# ​Intuitive touch-screen interface menus
# Compact design / small footprint
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Related Products

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LabChart Data Acquisition
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Dissection Tool Kit
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Gas Supply Manifold
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Buffer filler system - 625FS
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Vacuum Package
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Documentation

Click here
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Data Sheet
User Guide
User
​Manual
Normalization Guide
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Accessories

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​​​Add-Ons:​​
  • ​​Data Acquisition - LabChart ​
  • Computer Package (Desktop) 
  • Dissection Stereo Microscope
  • Light Source 
  • Dissection Tool Kit
  • Heating Bath Circulator
  • Vacuum Package
  • ​​Buffer Filler System - 625FS
  • Gas supply manifold
  • pH Electrode & pH Meter License 
  • Volume Reducing Insert
  • Tungsten Wire - 25µm, 15µm or 10μm
  • Mounting Pins 100µm, 200µm, 250µm, 300µm, or 400µm (*2)
  • Service & Maintenance Agreement
  • Extended warranty +3 years (*1)

*1 2-Years of Warranty included in purchase
*2 200µm mounting pins included in purchase
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Citations

Click here
WIRE MYOGRAPHY
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
Organ Bath System - 720MO
ORGAN BATH
​Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
Organ Bath System - 720MO
​Muscle Strip System - 820MS
​​​PRESSURE MYOGRAPHY
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
MUSCLE STRIP
Muscle Strip System - 820MS
MyoDynamics Muscle Strip System - 840MD
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  • Products
    • Wire Myograph Systems >
      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Pressure Myograph Systems >
      • Pressure Myography
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
    • Organ Bath Systems >
      • Organ Bath
      • Organ Bath System - 720MO
      • Muscle Strip System - 820MS
    • Muscle Strip Systems >
      • Muscle Strip Systems
      • Muscle Strip System - 820MS
      • MyoDynamics Muscle Strip System - 840MD
    • Accessories >
      • Buffer Filler System
      • FlowMeter - 162FM
      • Software >
        • For Wire Myograph Systems
        • For Pressure Myograph Systems
      • Stimulators >
        • Stimulator - CS4/CS8
        • Stimulator - CS4+
  • Resources
    • Blog
    • Myograph Training
    • Service & Development
    • Software Downloads >
      • DMT Device Enabler
      • DMT MyoVIEW 5
  • About us
  • Contact