High-throughput 4-channel design
Four chambers allow vessels or tissue rings to be studied simultaneously, supporting repetitive concentration-response protocols and treatment-control comparisons.
Multi Myograph System – 620M
4-channel wire myography for high-throughput vascular reactivity studies
The DMT 620M is a robust four-channel wire myograph for in vitro studies of vascular structure and function. It supports isometric contraction and relaxation studies using small arteries, larger vessels and a broad range of tissue ring preparations.
Four chambers
Study four vessels or tissue rings simultaneously.
Manual normalization
Standardize passive length-tension conditions.
MyoDAQ ready
USB communication and four analogue outputs.
4
independent experimental chambers
Why choose 620M
A trusted platform for reproducible vascular pharmacology and physiology
The 620M is designed for laboratories that need a flexible, durable and practical wire myograph for concentration-response curves, compound testing and parallel studies of individual vessel segments.
Small and larger ring preparations
Jaw and pin mounts support work with small vessels as well as larger ring segments, providing flexibility across different tissues and experimental protocols.
Controlled chamber conditions
Built-in heating, individual gas inflow and chamber drainage help maintain stable experimental conditions across all four channels.
Manual normalization workflow
Passive length-tension relationships can be determined following mounting and equilibration to improve consistency between vessel segments and experiments.
Direct data communication
The interface provides calibration functions, analogue output channels and USB communication for compatible DMT acquisition workflows.
Expandable laboratory setup
Multiple 620M systems can be arranged side by side, particularly when combined with the Buffer Filler System – 625FS for expanded experimental capacity.
System overview
Classic wire myography with four individually controlled chambers
Each 620M myograph unit has a centrally positioned, acid-resistant stainless-steel chamber. Tissue supports, either jaws or pins, are located inside the chamber with one side attached to the force transducer and the other to a precision micrometer.
During experiments, compounds can be added directly to the individual baths while contraction and relaxation are measured under isometric conditions.
Four independent chambers
Run parallel vessel or tissue ring studies in separated baths.
Jaw and pin mounting
Select the mounting approach according to vessel size, tissue
type and protocol.
Integrated control
Maintain chamber temperature, gassing and drainage through the
shared interface.
Manual normalization
Standardize passive length-tension conditions before active
experimental protocols.
Applications
Vascular physiology and pharmacological tissue reactivity
The 620M is suited to studies of vascular contraction, relaxation and reactivity in small arteries, larger vessels and other ring-mounted preparations.
Its four-chamber format supports concentration-response protocols, compound testing and experiments where individual preparations need to be studied in separate baths.
Hypertension
Atherosclerosis
Diabetes
Pre-eclampsia
COPD and asthma
Gastrointestinal research
Bladder research
01
Vascular contraction and relaxation
Measure active force development and relaxation under controlled isometric conditions.
02
Concentration-response studies
Run repeated pharmacological protocols across four independent experimental chambers.
03
Small-artery research
Support ring-mounted small-vessel preparations using the appropriate jaw mounting configuration.
04
Larger vessels and tissue rings
Study aorta, carotid artery, trachea, intestine, bladder and related ring-mounted tissue preparations.
System components
Integrated hardware for chamber control and force measurement
The 620M workflow combines four myograph chamber units with the shared Multi Interface for environmental control, calibration and communication with the selected data-acquisition setup.
620M chamber unit
Supports ring-mounted vessel segments using jaw or pin mounting, with precision mechanical adjustment and sensitive isometric force measurement.
Multi Interface
Provides shared control of heating, gassing, drainage, selectable force range, calibration and direct data communication across all four channels.
Product videos
Explore the 620M setup and operating principles
DMT product and how-to videos provide practical guidance for system setup, calibration, mounting, normalization and maintenance.
Introduction
View product videos
System introduction
Overview of the 620M and its principal components.
Setup
View product videos
System setup
Guidance for preparing the 620M for experimental use.
Calibration
View product videos
Force calibration
Calibration guidance for consistent force measurement.
Mounting
View how-to videos
Jaw and pin workflows
Mount changes, alignment and vessel-mounting guidance.
Normalization
View how-to videos
Normalization guidance
Manual normalization and micrometer-adjustment guidance.
Maintenance
View how-to videos
Cleaning and service
Routine cleaning, maintenance and transducer guidance.
Technical data
Key 620M specifications
Core chamber, temperature, transducer and output specifications for planning a complete 620M installation.
The 620M uses manual normalization. Vessel handling, mounting
quality, equilibration time and consistent normalization procedures
remain important for reproducible vascular reactivity data.
Chamber
- Number of chambers
- 4
- Minimum volume, jaw mount
- 3.8 ml
- Minimum volume, pin mount
- 2.0 ml
- Chamber material
- Acid-resistant stainless steel
- Vessel size, jaw mount
- >30 µm
- Vessel size, pin mount
- >450 µm
- Normalization
- Manual
- Micrometer resolution
- 0.01 mm
- Mounting type
- Jaws and pins
Temperature
- Temperature range
- 15.0 to 50.0 °C
- Temperature resolution
- 0.1 °C
- Temperature stability
- ±0.2 °C
- Heating
- Yes
Transducer
- Output reading
- mN or g
- Selectable force range
- ±200 / ±400 / ±800 / ±1600 mN
- Force resolution
- 0.01 mN
- Force calibration
- Yes
Data output
- Digital communication
- USB 2.0
- Analogue output channels
- 4
- Analogue output range
- ±2.5 V
Configuration guidance
Plan the complete 620M laboratory workflow
The appropriate configuration depends on preparation type, acquisition preferences, laboratory infrastructure and required experimental throughput.
Core workflow items
Typical complete workflows include MyoDAQ or LabChart acquisition, a compatible computer, dissection stereo microscope, light source, dissection tools, heating bath or circulator and vacuum package.
Useful additions
Common additions include the Buffer Filler System – 625FS, gas supply manifold, installation kit, volume-reducing inserts, tungsten wire and mounting pins in different diameters.
Service and long-term support
Training, service agreements, spare force transducers and extended warranty options can support consistent operation and laboratory uptime in high-use environments.
Resources
620M documentation and supporting guidance
Use the product data sheet, manuals, normalization guidance and software resources when evaluating, configuring or operating the 620M.
620M product data sheet
Product overview, applications and technical specifications.
→620M user manual
Detailed system setup, calibration and maintenance information.
→620M user guide
Practical reference for routine preparation and system use.
→Normalization guide
DMT guidance for wire-myograph normalization workflows.
→Software downloads
Find DMT acquisition software, installers and related tools.
→Guides and manuals
Browse additional DMT product and application documentation.
→Wire myograph systems
Compare DMT wire-myograph platforms and measurement workflows.
→Training and installation
Support laboratory onboarding and consistent system operation.
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