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More about

WIRE

Myography
See Wire Systems
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Basic Tissue Properties

  • Vascular smooth muscle function
  • Vascular endothelium function 
  • Length-tension relationships (also motorized) 
  • Wall tension & morphometric measurements 
  • Assessment of pharmacological reactivity
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Pharmacology

  • Quantify the effect of treatment with contractile and relaxing agents 
  • Receptor studies, localization and characterization of receptors 
  • Affinity & efficacy studies of agonists & antagonists 
  • Drug studies efficiency & efficacy, drug discovery & safety pharmacology
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Physiology Changes & Pathology

  • Hypertension
  • Atherosclerosis 
  • Diabetes
  • Ageing 
  • Ischemic heart disease & heart failure 
  • Tumors & angiogenesis 
  • Gastrointestinal & urogenital disease Pregnancy, preeclampsia 
  • Exercise physiology, muscular degenerative diseases
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Vasaoactive Mechanisms

  • Endothelium: role of endothelium-derived relaxing factor (NO), prostaglandins and endothelium-derived hyperpo-larizing factor (EDHF) 
  • Smooth muscle: role of calcium and potassium and other ion channels 
  • Perivascular and intramural nerves: role of endogenously released transmitters ​

The Wire Myograph enables detailed examination of small blood vessels (internal diameter 60 μm - 10 mm), focusing on their morphology and responsiveness to hormones and other agonists. These vessels are mounted as ring preparations by threading them onto two stainless steel or tungsten wires, which are then secured to two supports.
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One support is attached to a micrometer, allowing precise control of the vessel's circumference. The other support is connected to a force transducer to measure tension development. The preparation is maintained in a chamber filled with a physiological salt solution at 37°C, bubbled with oxygen, ensuring the vessels remain viable for several hours.

After mounting and equilibration, the passive length-tension relationships of the vessels are determined through a normalization procedure. The vessel circumferences are kept constant during experiments and examined under isometric conditions. Compounds are added directly to the chamber, continuously monitoring vessel tension. This setup allows for the comparison of vessel reactivity and morphology between patient or test groups and control groups.

Wire myograph systems are used in various established research areas, and the possibility of investigating vascular and other smooth muscles is limited only by researchers' imaginations.



Wire Myograph Systems

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Multi Wire Myograph System - 620M

This 4-channel multi myograph system is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in vitro studies of small and large blood vessels, trachea, or gut mounted as larger ring preparations (up to 10mm).​​​
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Auto. Multi Wire Myograph System - 630MA

Making it easier… the 4-channel system adds the ease of automating the normalization procedures so that calculations and preload tension is easily set. Following mounting and equilibration, passive length-tension relationships are determined by a standardized procedure. 
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​Single Wire Myograph System - 320A

Ideal for studying a single vessel with a diameter of 60μm - 3mm. The vessel is mounted as a ring preparation by threading it over two parallel stainless steel wires and securing the wires to two supports or "jaws."
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Dual-Channel Wire Myograph System - 420A​

​The Dual Wire Myograph System allows you to examine vascular reactivity and functional responses on small isolated arteries. Model 420A is ideal for testing two vessels with diameters of 30 μm simultaneously - 3 mm, independently.
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Confocal Wire Myograph System 360CW

Designed to provide very close optical access to the mounted artery or tissue segment, thereby allowing high-resolution images of fluorescent dyes or markers by laser scanning confocal microscopy (LSCM).
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WIRE MYOGRAPH SYSTEMS
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
​Dual Chamber Wire Myograph System - 420A
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
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​​ORGAN BATH SYSTEMS
Multi Myograph System - 620M
​Organ Bath System - 751MT​
Organ Bath System - 820MO
​
​MUSCLE STRIP SYSTEMS
Tissue Puller - 560TP
MyoDynamics Muscle Strip System - 840MD
​
​​​PRESSURE MYOGRAPH SYSTEMS
Pressure Myograph System - 110PXL
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
Pressure Myograph System - 114PB
Pressure Myograph System - 114PN
SUPPORT
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Myograph Training/Installation
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© 2025 Danish Myo Technology A/S
  • Products
    • Muscle Strip Systems >
      • Tissue Puller System - 560TP
      • MyoDynamics Muscle Strip System - 840MD
    • Organ Bath System >
      • Organ Bath System - 751MT
      • Organ Bath System - 820MO
    • Pressure Myograph Systems >
      • Pressure Myograph System - 110PXL
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
      • Pressure Myograph System - 114PB
      • Pressure Myograph System - 114PN
      • Pressure Myograph System - 120CP
    • Wire Myograph Systems >
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Dual Wire Myograph System - 420A
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Myograph Software >
      • MyoNORM
      • MyoDAQ Acquisition
      • MyoVIEW 5
      • MyoPULSE
    • Accessories & Parts >
      • Buffer Filler System
      • Dissection & Mounting
      • FlowMeter - 162FM
      • Stimulators >
        • Stimulator - CS4+
        • Stimulator - CS8
      • Transducers
  • Support
    • Guides, Videos & More >
      • Product Videos
      • Guides & Manuals
      • Protocols/Articles
      • Software Downloads
      • How To Videos
    • Myograph Training/Installation
    • System Maintenance
  • Blog
  • About us
  • Contact