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      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Dual Wire Myograph System - 420A
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
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More about

WIRE

Myography
See Wire Systems
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Basic Tissue Properties

  • Vascular smooth muscle function
  • Vascular endothelium function 
  • Length-tension relationships (also motorized) 
  • Wall tension & morphometric measurements 
  • Assessment of pharmacological reactivity
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Pharmacology

  • Quantify the effect of treatment with contractile and relaxing agents 
  • Receptor studies, localization and characterization of receptors 
  • Affinity & efficacy studies of agonists & antagonists 
  • Drug studies efficiency & efficacy, drug discovery & safety pharmacology
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Physiology Changes & Pathology

  • Hypertension
  • Atherosclerosis 
  • Diabetes
  • Ageing 
  • Ischemic heart disease & heart failure 
  • Tumors & angiogenesis 
  • Gastrointestinal & urogenital disease Pregnancy, preeclampsia 
  • Exercise physiology, muscular degenerative diseases
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Vasaoactive Mechanisms

  • Endothelium: role of endothelium-derived relaxing factor (NO), prostaglandins and endothelium-derived hyperpo-larizing factor (EDHF) 
  • Smooth muscle: role of calcium and potassium and other ion channels 
  • Perivascular and intramural nerves: role of endogenously released transmitters ​
The Wire Myograph allows the examination of small vessels (internal diameter 60 μm - 10 mm) in terms of morphology and responsiveness to hormones and other agonists. The small vessels are mounted as ring preparations by threading them onto two stainless steel or tungsten wires and securing the wires to two supports.

One support is then attached to a micrometer, allowing control of vessel circumference. The other support is attached to a force transducer for the measurement of tension development. The whole preparation is kept in a chamber with physiological salt solution at 37°C, bubbled with oxygen. Vessels maintained in Wire Myographs are viable for several hours. ​

Following mounting and equilibration, the passive length-tension relationships of the vessels are determined; a normalization procedure. During the actual experiments, vessels' circumference are kept constant and vessels are examined under isometric conditions. Compounds are added directly to the chamber and vessel tension is monitored. Furthermore, it is possible to compare vessels from patients or test groups with those of control, not only in terms of vessel reactivity to various compounds but also in terms of morphology. 
​
The following lists are a few of the established areas of investigation for Wire Myograph systems. Many more investigation possibilities for vascular and other smooth muscle may be added through the imagination of researchers such as yourself.

Wire Myograph Systems

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Multi Wire Myograph System - 620M

This 4-channel multi myograph system is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in vitro studies of small and large blood vessels, trachea, or gut mounted as larger ring preparations (up to 10mm).​​​
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Auto. Multi Wire Myograph System - 630MA

Making it easier… the 4-channel system adds the ease of automating the normalization procedures so that calculations and preload tension is easily set. Following mounting and equilibration, passive length-tension relationships are determined by a standardized procedure. 
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​Single Wire Myograph System - 320A

Ideal for studying a single vessel with a diameter of 60μm - 3mm. The vessel is mounted as a ring preparation by threading it over two parallel stainless steel wires and securing the wires to two supports or "jaws."
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Confocal Wire Myograph System 360CW

Designed to provide very close optical access to the mounted artery or tissue segment, thereby allowing high-resolution images of fluorescent dyes or markers by laser scanning confocal microscopy (LSCM).
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WIRE MYOGRAPHY
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
​Dual Chamber Wire Myograph System - 420A
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
​​​PRESSURE MYOGRAPHY
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
​​ORGAN BATH
​Organ Bath System - 820MO
​
MUSCLE STRIP
MyoDynamics Muscle Strip System - 840MD
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  • Products
    • Wire Myograph Systems >
      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Dual Wire Myograph System - 420A
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Pressure Myograph Systems >
      • Pressure Myography
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
    • Organ Bath Systems >
      • Organ Bath
      • Organ Bath System - 820MO
    • Muscle Strip Systems >
      • Muscle Strip Systems
      • MyoDynamics Muscle Strip System - 840MD
    • Accessories & Spare Parts >
      • Accessories
      • Buffer Filler System
      • Dissection & Mounting
      • FlowMeter - 162FM
      • Software >
        • For Wire Myograph Systems
        • For Pressure Myograph Systems
      • Stimulators >
        • Stimulator - CS4+
        • Stimulator - CS8
      • Transducers
  • Resources
    • Guides, Videos & More
    • Myograph Training/Installation
    • System Maintenance
    • Software Downloads >
      • DMT Device Enabler
      • DMT MyoVIEW 5
      • DMT MyoNORM
  • Blog
  • About us
  • Contact