|
More about
WIREMyography
|
|
Basic Tissue Properties
|
Pharmacology
|
Physiology Changes & Pathology
|
Vasaoactive Mechanisms
|
The Wire Myograph enables detailed examination of small blood vessels (internal diameter 60 μm - 10 mm), focusing on their morphology and responsiveness to hormones and other agonists. These vessels are mounted as ring preparations by threading them onto two stainless steel or tungsten wires, which are then secured to two supports.
One support is attached to a micrometer, allowing precise control of the vessel's circumference. The other support is connected to a force transducer to measure tension development. The preparation is maintained in a chamber filled with a physiological salt solution at 37°C, bubbled with oxygen, ensuring the vessels remain viable for several hours.
After mounting and equilibration, the passive length-tension relationships of the vessels are determined through a normalization procedure. The vessel circumferences are kept constant during experiments and examined under isometric conditions. Compounds are added directly to the chamber, continuously monitoring vessel tension. This setup allows for the comparison of vessel reactivity and morphology between patient or test groups and control groups.
Wire myograph systems are used in various established research areas, and the possibility of investigating vascular and other smooth muscles is limited only by researchers' imaginations.
One support is attached to a micrometer, allowing precise control of the vessel's circumference. The other support is connected to a force transducer to measure tension development. The preparation is maintained in a chamber filled with a physiological salt solution at 37°C, bubbled with oxygen, ensuring the vessels remain viable for several hours.
After mounting and equilibration, the passive length-tension relationships of the vessels are determined through a normalization procedure. The vessel circumferences are kept constant during experiments and examined under isometric conditions. Compounds are added directly to the chamber, continuously monitoring vessel tension. This setup allows for the comparison of vessel reactivity and morphology between patient or test groups and control groups.
Wire myograph systems are used in various established research areas, and the possibility of investigating vascular and other smooth muscles is limited only by researchers' imaginations.
Wire Myograph Systems
Auto. Multi Wire Myograph System - 630MAMaking it easier… the 4-channel system adds the ease of automating the normalization procedures so that calculations and preload tension is easily set. Following mounting and equilibration, passive length-tension relationships are determined by a standardized procedure.
|
|
|
