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More about
PRESSUREMYOGRAPHY
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Basic Tissue Properties
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Pharmacology & Physiology
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Pathology
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Vasaoactive Mechanisms
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Shape Divider - Style pyramids
The Pressure Myograph Systems are used to measure the physiological function and properties of small arteries, veins and other vessels. The system also allows the study of pharmacological effects of drugs and other vasoactive compounds on small isolated vessels under near physiological conditions. In these systems, vessels retain many of their in vivo characteristics.
In pressure myography, an intact small segment of an artery or vein is mounted onto two small glass cannula and pressurized to a suitable transmural pressure. This near physiological condition permits the investigation of intrinsic (myogenic) responses which can be extrapolated to the in vivo behavior of the entire vascular bed (auto-regulation).
Various pharmacological agents can then be studied by adding these to the superfusate or luminal solution. Both constriction and dilation can be readily measured as changes in diameter of the preparation via digital video edge-detection. Since intrinsic myogenic constriction is present, the role and function of the endothelium for this phenomenon can be studied.
Specialized versions of pressure myograph chambers can accommodate special research need like imaging (confocal) or electrophysiology. Pressure-based culture myographs are a new tool that provides long term tissue preservation to study molecular changes introduced via viral vectors, siRNA or other interventions. In this way, mechanistic and molecular physiological and pharmacological studies can be done on intact tissue under near physiological conditions. Overall the pressure myograph technique is a very powerful tool in the hands of the dedicated vascular physiologist or pharmacologist.
The following lists are a few of the established areas of investigation for the pressure myograph systems. In the future, many more areas will be added to these lists through ongoing product development and the research performed by myograph users.
In pressure myography, an intact small segment of an artery or vein is mounted onto two small glass cannula and pressurized to a suitable transmural pressure. This near physiological condition permits the investigation of intrinsic (myogenic) responses which can be extrapolated to the in vivo behavior of the entire vascular bed (auto-regulation).
Various pharmacological agents can then be studied by adding these to the superfusate or luminal solution. Both constriction and dilation can be readily measured as changes in diameter of the preparation via digital video edge-detection. Since intrinsic myogenic constriction is present, the role and function of the endothelium for this phenomenon can be studied.
Specialized versions of pressure myograph chambers can accommodate special research need like imaging (confocal) or electrophysiology. Pressure-based culture myographs are a new tool that provides long term tissue preservation to study molecular changes introduced via viral vectors, siRNA or other interventions. In this way, mechanistic and molecular physiological and pharmacological studies can be done on intact tissue under near physiological conditions. Overall the pressure myograph technique is a very powerful tool in the hands of the dedicated vascular physiologist or pharmacologist.
The following lists are a few of the established areas of investigation for the pressure myograph systems. In the future, many more areas will be added to these lists through ongoing product development and the research performed by myograph users.
Shape Divider - Style pyramids
Pressure Myograph Systems
Pressure Pulsation Myograph 112PPThe Pressure Pulsation Myograph System - 112PP is an ideal system used to study the structure and function of isolated sections of small vessels (diameter >60 μm) under near-physiological conditions. Vessel diameters can be measured in response to pharmacological and physiological stimuli.
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Pressure Myograph 114PThe Pressure Myograph System - 114P is an ideal system used to study the structure and function of isolated sections of small vessels (diameter >60 μm) under near-physiological conditions. Vessel diameters can be measured in response to pharmacological and physiological stimuli.
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