Diameter and myogenic tone
Track changes in vessel diameter during pressure steps, vasoactive compound exposure and myogenic constriction or relaxation protocols.
Pressure Myograph Systems
Study intact pressurized vessels under near-physiological conditions
DMT pressure myograph systems support ex vivo studies of cannulated arteries, veins and other vessel segments where transmural pressure, vessel diameter, flow, pulsation, wall mechanics or high-resolution imaging are central to the experimental question.
Physiological pressure
Study intact vessels under controlled transmural pressure.
Live vessel tracking
Follow diameter, lumen and wall parameters during experiments.
Specialized configurations
Flow, pulsation, blind-sac, force and confocal imaging.
Intact vessels
Pressure, diameter, flow and vascular function
What pressure myographs measure
Dynamic vascular responses in cannulated vessel preparations
Pressure myography maintains the vessel as an intact tubular preparation. This allows diameter, tone, wall structure and pressure-dependent responses to be studied without mounting the vessel as a ring.
Flow and endothelial response
Apply controlled luminal flow to investigate flow-mediated dilation, shear-dependent signaling and luminal compound exposure.
Wall mechanics and imaging
Measure lumen and wall dimensions, evaluate vascular remodeling or combine pressurization with fluorescence and high-resolution microscopy.
Research applications
Vascular function, pharmacology and structural biology
Pressure myographs are used when vascular behavior should be examined under pressure and, where required, flow or pulsation conditions that more closely reproduce the mechanical environment of the intact vessel.
System choice depends on vessel dimensions, required endpoint, force measurement, flow, pulsation and optical-access needs.
01
Myogenic tone and reactivity
Investigate pressure-dependent constriction, relaxation and vasoactive compound responses in resistance arteries and other vessels.
02
Flow-mediated dilation
Study endothelial responses to controlled flow, shear stress and luminal pharmacological exposure.
03
Pressure and pulsation
Evaluate vascular responses to steady or pulsatile pressure patterns and changes in pressure amplitude or frequency.
04
Wall mechanics and remodeling
Quantify lumen diameter, wall thickness, compliance and structural-functional changes in disease or ageing models.
05
Vascular pharmacology
Apply compounds to the luminal or abluminal side and measure effects on vessel tone, diameter and pressure-dependent behavior.
06
High-resolution imaging
Combine intact-vessel pressurization with fluorescence, intracellular calcium measurements or confocal microscopy.
Pressure myograph systems
Compare DMT pressure myograph configurations
The portfolio covers large vessels, standard small-vessel myography, pulsatile pressure, blind-sac preparations, pressure and flow without longitudinal force, and confocal-compatible imaging.
Large-vessel pressure myography
Pressure Myograph System – 110PXL
Pressure myograph system for large arteries, veins and other larger vessel segments where diameter changes, vascular reactivity and compliance are studied under controlled pressure.
Vessel direction
Large arteries and veins
Vessel diameter
Approximately 1.5–6.0 mm
Primary endpoints
Diameter, reactivity and compliance
Best fit
Large-vessel physiology and mechanics
Pulsation and flow
Pressure Pulsation Myograph System – 112PP
Small-vessel pressure myograph for structure and function studies requiring simulated pulsation, pressure control, flow-related workflows and live wall tracking.
Vessel direction
Small arteries and veins
Pressure mode
Steady and simulated pulsatile pressure
Flow
Flow-related study capability
Best fit
Pulsation and advanced hemodynamic studies
Standard small-vessel platform
Pressure Myograph System – 114P
Core pressure myograph platform for small arteries, veins and other vessels studied under near-physiological pressure, with pharmacology, wall tracking, flow-related and force-measurement capability.
Vessel direction
Small arteries and veins
Pressure
Controlled transmural pressure
Tracking
Diameter and wall tracking
Best fit
Standard pressure myography workflows
Blind-sac configuration
Pressure Myograph System – 114PB
Blind-sac pressure or perfusion myograph system for small-vessel experiments where the preparation or protocol requires a specific closed-end mounting and pressure configuration.
Vessel direction
Small vessels and specialized preparations
Configuration
Blind-sac mounting
Study mode
Pressure or perfusion studies
Best fit
Closed-end vessel preparations
Pressure and flow
Pressure Myograph System – 114PN
Pressure myograph for small arteries, veins and other vessels where researchers require pressure, flow and wall-tracking studies without longitudinal force measurement.
Vessel direction
Small arteries and veins
Pressure and flow
Supported
Force transducer
Not included in this configuration
Best fit
Focused diameter and flow studies
Confocal and high-resolution imaging
Imaging Pressure Myograph System – 120CP
Pressure myograph system for high-resolution imaging studies where intracellular processes in vascular smooth muscle or endothelial cells are measured in intact pressurized vessels.
Vessel direction
Pressurized vessels above approximately 40 µm
Optical access
High-magnification and confocal workflows
Typical endpoint
Fluorescence and intracellular signaling
Best fit
Force-independent imaging studies
Quick comparison
First-pass pressure myograph selection guide
Use this comparison to identify the most relevant system direction before confirming the chamber, interface, software and accessory configuration.
| Selection factor | 110PXL | 112PP | 114P | 114PB | 114PN | 120CP |
|---|---|---|---|---|---|---|
| Primary direction | Large-vessel studies | Pulsation and flow | Standard small-vessel myography | Blind-sac preparation | Pressure and flow without force | High-resolution imaging |
| Typical vessel | Large arteries and veins | Small arteries and veins | Small arteries and veins | Small closed-end preparations | Small arteries and veins | Imaging-compatible pressurized vessels |
| Pressure control | Yes | Yes | Yes | Yes | Yes | Yes |
| Flow direction | Protocol-dependent | Yes | Yes | Perfusion-specific | Yes | Imaging-focused |
| Pulsation | No | Yes | No | No | No | No |
| Longitudinal force | Configuration-dependent | Supported | Supported | Protocol-dependent | No | Not the primary endpoint |
| Main reason to choose | Large-vessel diameter and compliance | Simulated pulsatile conditions | Versatile standard pressure myography | Blind-sac mounting requirement | Simplified pressure and flow workflow | Confocal or high-magnification imaging |
| Product page | View 110PXL | View 112PP | View 114P | View 114PB | View 114PN | View 120CP |
How to choose
Start with the vessel geometry and biological endpoint
Pressure myograph selection is not determined by vessel size alone. Flow, pulsation, force measurement, blind-sac mounting and optical access can change the required chamber and interface.
Confirm the complete experiment before selecting the chamber.
Cannulas, camera, microscope, pressure control, flow measurement
and imaging requirements must work together.
Vessel type and dimensions
Define the species, vessel type, expected internal diameter,
wall thickness and available segment length.
Standard or blind-sac
Confirm whether both vessel ends will be cannulated or whether
the preparation requires a closed-end blind-sac configuration.
Pressure protocol
Determine the pressure range, pressure-step sequence and whether
steady or pulsatile pressure is required.
Flow requirements
Confirm whether the experiment requires no flow, controlled
flow, flow-mediated dilation or luminal perfusion.
Longitudinal force
Decide whether axial or longitudinal force measurement is part
of the protocol or whether diameter tracking is sufficient.
Tracking and analysis
Define whether diameter, lumen, wall thickness, myogenic tone or
derived vascular parameters must be measured.
Optical access
Confirm the microscope type, objective working distance,
magnification, fluorescence and confocal requirements.
Supporting equipment
Plan the camera, stage micrometer, heating, pressure source,
flowmeter, cannulas, gas supply and acquisition workflow.
Software and support
Complete the pressure-myography workflow
Reliable pressure-myograph data depend on vessel cannulation, pressure calibration, leak testing, camera alignment, live tracking and routine chamber maintenance.
Vessel tracking and analysis
Track diameter, lumen and wall parameters during pressure, pharmacology, flow and imaging protocols.
Explore MyoVIEWPressure and flow accessories
Configure pressure sources, flow measurement, cannulas, cameras, microscopes and other supporting components.
Explore accessoriesInstallation and training
Support new users with setup, vessel cannulation, pressure calibration, leak checks, tracking and daily maintenance.
Explore training
Resources
Pressure-myograph comparison, videos and technical guidance
Use the DMT resources below when selecting, installing or operating a pressure-myograph system.
Pressure comparison chart
Compare pressure, flow, force, pulsation, tracking and imaging capability.
→MyoVIEW
Review vessel tracking and pressure-myograph analysis software.
→Product videos
Review pressure-myograph introductions and application videos.
→How-to videos
Access calibration, pressure checks, cannula and maintenance guidance.
→Guides and manuals
Find documentation for installation, calibration and operation.
→Protocols and articles
Browse application-focused pressure-myography resources.
→Training and installation
Plan setup, cannulation training and laboratory onboarding.
→Technical support
Request support for setup, tracking, operation or maintenance.
→
Configuration guidance
Need help selecting the right pressure myograph?
Share the vessel type, expected diameter and length, pressure range, flow and pulsation requirements, force endpoint, imaging setup and preferred tracking workflow. DMT can help define the appropriate chamber, interface and supporting configuration.