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More about

PRESSURE

MYOGRAPHY
See Pressure Systems
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Basic Tissue Properties

  • Small vessel function, vascular diameter 
  • Vascular smooth muscle function 
  • Vascular endothelium function 
  • Wall tension & thickness measurements 
  • Vessels isolated from animal or human 
  • Assessment of local vascular reactivity 
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Pharmacology & Physiology

  • Quantify the effect of treatment with e.g. ACE- inhibitors, statins, glitazones or insulin 
  • Receptor studies, localization and characterization of receptors 
  • Affinity and efficacy studies of vasoactive agonists and antagonists
  • Aging, pregnancy, preeclampsia 
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Pathology

  • Hypertension
  • Atherosclerosis
  • Diabetes
  • Ischemia, heart disease and heart failure
  • Tumors and angiogenesis
  • Heart and lung diseases
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Vasaoactive Mechanisms

  • Endothelium: role of endothelium-derived relaxing factor (NO), prostaglandins and endothelium-derived hyperpolarizing factor (EDHF) 
  • Smooth muscle: role of calcium and potassium and other ion channels
  • Perivascular and intramural nerves: role of endogenous released transmitters
Pressure Myograph Systems are used to measure small arteries, veins, and other vessels' physiological function and properties. The system also allows studying pharmacological effects of drugs and other vasoactive compounds on small isolated vessels under near-physiological conditions. In these systems, vessels retain many of their in vivo characteristics.  
              
In pressure myography, an intact small segment of an artery or vein is mounted onto two small glass cannula and pressurized to a suitable transmural pressure. This near physiological condition permits the investigation of intrinsic (myogenic) responses, which can be extrapolated to the entire vascular bed's in vivo behavior (auto-regulation).

Various pharmacological agents can then be studied by adding these to the superfusate or luminal solution. Both constriction and dilation can be readily measured as changes in the diameter of the preparation via digital video edge-detection. Since intrinsic myogenic constriction is present, the endothelium's role and function for this phenomenon can be studied.

Specialized versions of pressure myograph chambers can accommodate particular research need like imaging (confocal) or electrophysiology. Pressure-based culture myographs are a new tool that provides long term tissue preservation to study molecular changes introduced via viral vectors, siRNA, or other interventions. In this way, mechanistic and molecular physiological and pharmacological studies can be done on intact tissue under near-physiological conditions. Overall, the pressure myograph technique is a very powerful tool in the dedicated vascular physiologist or pharmacologist's hands. 

The following lists are a few of the established areas of investigation for the pressure myograph systems. In the future, many more areas will be added to these lists through ongoing product development and the research performed by myograph users.​


Pressure Myograph Systems

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​Pressure Pulsation Myograph 112PP

Ideal system used to study the structure and function of isolated sections of small vessels (diameter >40μm) under near-physiological conditions. Vessel diameters can be measured in response to pharmacological and physiological stimuli. In addition, this system allows simulation of pulsations between 50 and 600BPM with a pressure difference up to 60mmHg.
See more
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Pressure Myograph 114P

Used to measure the physiological function and properties of small arteries, veins, and other vessels.  Study pharmacological effects of drugs and other vasoactive compounds under near-physiological conditions.  An intact segment is mounted onto two small glass cannulas and pressurized to a suitable transmural pressure. 
​
See more
WIRE MYOGRAPHY
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
​Dual Chamber Wire Myograph System - 420A
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
​​​PRESSURE MYOGRAPHY
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
​​ORGAN BATH
​Organ Bath System - 820MO
​
MUSCLE STRIP
MyoDynamics Muscle Strip System - 840MD
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  • Products
    • Wire Myograph Systems >
      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Dual Wire Myograph System - 420A
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Pressure Myograph Systems >
      • Pressure Myography
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
    • Organ Bath Systems >
      • Organ Bath
      • Organ Bath System - 820MO
    • Muscle Strip Systems >
      • Muscle Strip Systems
      • MyoDynamics Muscle Strip System - 840MD
    • Accessories & Spare Parts >
      • Accessories
      • Buffer Filler System
      • Dissection & Mounting
      • FlowMeter - 162FM
      • Software >
        • For Wire Myograph Systems
        • For Pressure Myograph Systems
      • Stimulators >
        • Stimulator - CS4+
        • Stimulator - CS8
      • Transducers
  • Resources
    • Guides, Videos & More
    • Myograph Training/Installation
    • System Maintenance
    • Software Downloads >
      • DMT Device Enabler
      • DMT MyoVIEW 5
      • DMT MyoNORM
  • Blog
  • About us
  • Contact