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More about
PRESSUREMYOGRAPHY
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Basic Tissue Properties
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Pharmacology & Physiology
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Pathology
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Vasaoactive Mechanisms
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Pressure Myograph Systems are used to measure small arteries, veins, and other vessels' physiological function and properties. The system also allows studying pharmacological effects of drugs and other vasoactive compounds on small isolated vessels under near-physiological conditions. In these systems, vessels retain many of their in vivo characteristics.
In pressure myography, an intact small segment of an artery or vein is mounted onto two small glass cannula and pressurized to a suitable transmural pressure. This near physiological condition permits the investigation of intrinsic (myogenic) responses, which can be extrapolated to the entire vascular bed's in vivo behavior (auto-regulation).
Various pharmacological agents can then be studied by adding these to the superfusate or luminal solution. Both constriction and dilation can be readily measured as changes in the diameter of the preparation via digital video edge-detection. Since intrinsic myogenic constriction is present, the endothelium's role and function for this phenomenon can be studied.
Specialized versions of pressure myograph chambers can accommodate particular research need like imaging (confocal) or electrophysiology. Pressure-based culture myographs are a new tool that provides long term tissue preservation to study molecular changes introduced via viral vectors, siRNA, or other interventions. In this way, mechanistic and molecular physiological and pharmacological studies can be done on intact tissue under near-physiological conditions. Overall, the pressure myograph technique is a very powerful tool in the dedicated vascular physiologist or pharmacologist's hands.
The following lists are a few of the established areas of investigation for the pressure myograph systems. In the future, many more areas will be added to these lists through ongoing product development and the research performed by myograph users.
In pressure myography, an intact small segment of an artery or vein is mounted onto two small glass cannula and pressurized to a suitable transmural pressure. This near physiological condition permits the investigation of intrinsic (myogenic) responses, which can be extrapolated to the entire vascular bed's in vivo behavior (auto-regulation).
Various pharmacological agents can then be studied by adding these to the superfusate or luminal solution. Both constriction and dilation can be readily measured as changes in the diameter of the preparation via digital video edge-detection. Since intrinsic myogenic constriction is present, the endothelium's role and function for this phenomenon can be studied.
Specialized versions of pressure myograph chambers can accommodate particular research need like imaging (confocal) or electrophysiology. Pressure-based culture myographs are a new tool that provides long term tissue preservation to study molecular changes introduced via viral vectors, siRNA, or other interventions. In this way, mechanistic and molecular physiological and pharmacological studies can be done on intact tissue under near-physiological conditions. Overall, the pressure myograph technique is a very powerful tool in the dedicated vascular physiologist or pharmacologist's hands.
The following lists are a few of the established areas of investigation for the pressure myograph systems. In the future, many more areas will be added to these lists through ongoing product development and the research performed by myograph users.
Pressure Myograph Systems
Pressure Pulsation Myograph 112PPIdeal system used to study the structure and function of isolated sections of small vessels (diameter >40μm) under near-physiological conditions. Vessel diameters can be measured in response to pharmacological and physiological stimuli. In addition, this system allows simulation of pulsations between 50 and 600BPM with a pressure difference up to 60mmHg.
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Pressure Myograph 114PUsed to measure the physiological function and properties of small arteries, veins, and other vessels. Study pharmacological effects of drugs and other vasoactive compounds under near-physiological conditions. An intact segment is mounted onto two small glass cannulas and pressurized to a suitable transmural pressure.
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