Tissue Organ Bath

Basic Tissue Properties

Vascular smooth muscle function
Vascular endothelium function
Length-tension relationships
Wall tension & morphometric measurements
Assessment of pharmacological reactivity

Pharmacology

Quantify the effect of treatment with contractile and relaxing agents
Receptor studies, localization and characterization of receptors
Affinity & efficacy studies of agonists & antagonists
Drug studies efficiency & efficacy, drug discovery & safety pharmacology

Physiology Changes & Pathology

Hypertension
Atherosclerosis
Diabetes
Ageing
Ischemic heart disease & heart failure
Tumors & angiogenesis
Gastrointestinal & urogenital disease pregnancy, preeclampsia
Exercise physiology, muscular degenerative diseases

Vasaoactive Mechanisms

Endothelium: role of endothelium-derived relaxing factor (NO), prostaglandins and endothelium-derived hyperpolarizing factor (EDHF)
Smooth muscle: role of calcium and potassium and other ion channels
Perivascular and intramural nerves: role of endogenously released transmitters

"The addictive workhorse for your routine high-throughput pharmacological studies on nearly all type of muscle."

An isolated organ bath assay is the classical pharmacological screening tool to assess concentration-response relationships in contractile tissue. Although a variety of molecular tools have become available in recent decades to assess cellular responses in high-throughput quantities, the organ bath assay is still considered a valuable tool for lead optimization and for the elucidation of the mechanism of action. In addition, organ bath assays are widely used in preclinical safety studies.

The most common application of the organ bath assay is in cardiovascular research, using isolated aortic rings, heart tissue (papillary muscle, left ventricles) or arteries. For studying gastro-intestinal effects, preparations of ileum and colon are often used, but also gastric antral muscle and sphincter may be studied.

Respiratory effects can be studied in isolated tracheal rings, phrenic diaphragm preparations, pulmonary arterial smooth muscle and even lung parenchyma. Other smooth muscle preparations that are used in organ bath research are urinary bladder, penile muscle strips and prostate.

Organ Bath Systems

Multi Myograph System - 620M

The Multi Myograph System - model 620M is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in-vitro studies of vascular structure and function. The range of applications is countless within isometric contraction and dilatation of smaller arteries, larger vessels such as the carotid artery and aorta, trachea, intestine, bladder, and many more.

Organ Bath System - 751mT

The Organ Bath System - 751mT is a smart, cost-effective organ bath system designed for versatility across a wide range of physiological studies. Weather working with cardiac, skeletal, or smooth muscle, its modular setup with interchangeable tissue holders and chambers makes it an ideal solution for both teaching and research environments.

Organ Bath System - 820MO

Ideal system for measuring mechanical properties of isolated muscle tissue such as TA, Soleus, EDL and/or vascular reactivity of larger ring-mounted segments of vascular smooth muscle, trachea, bronchial, lung, gut, uterine, colon, veins etc.

Organ Bath System - 752eT

The Organ Bath 752eT is a compact, single‑channel organ bath system designed for isolated tissue experiments in physiology and pharmacology. It provides reliable force measurement for smooth muscle and vascular tissue studies, making it ideal for teaching laboratories and cost‑efficient research workflows.