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More about

ORGAN BATH

SYSTEMS
See Tissue Organ Bath Systems
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Basic Tissue Properties

  • Vascular smooth muscle function
  • Vascular endothelium function 
  • Length-tension relationships (also motorized) 
  • Wall tension & morphometric measurements 
  • Assessment of pharmacological reactivity
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Pharmacology

  • Quantify the effect of treatment with contractile and relaxing agents 
  • Receptor studies, localization and characterization of receptors 
  • Affinity & efficacy studies of agonists & antagonists 
  • Drug studies efficiency & efficacy, drug discovery & safety pharmacology
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Physiology Changes & Pathology

  • Hypertension
  • Atherosclerosis 
  • Diabetes
  • Ageing 
  • Ischemic heart disease & heart failure 
  • Tumors & angiogenesis 
  • Gastrointestinal & urogenital disease pregnancy, preeclampsia 
  • Exercise physiology, muscular degenerative diseases
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Vasaoactive Mechanisms

  • Endothelium: role of endothelium-derived relaxing factor (NO), prostaglandins and endothelium-derived hyperpolarizing factor (EDHF) 
  • Smooth muscle: role of calcium and potassium and other ion channels 
  • Perivascular and intramural nerves: role of endogenously released transmitters ​
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"The addictive workhorse for your routine high-throughput pharmacological studies on nearly all type of muscle."
​An isolated organ bath assay is the classical pharmacological screening tool to assess concentration-response relationships in contractile tissue. Although a variety of molecular tools have become available in recent decades to assess cellular responses in high-throughput quantities, the organ bath assay is still considered a valuable tool for lead optimization and for the elucidation of the mechanism of action. In addition, organ bath assays are widely used in preclinical safety studies.​ 

The most common application of the organ bath assay is in cardiovascular research, using isolated aortic rings, heart tissue (papillary muscle, left ventricles) or arteries. For studying gastro-intestinal effects, preparations of ileum and colon are often used, but also gastric antral muscle and sphincter may be studied. 
             
Respiratory effects can be studied in isolated tracheal rings, phrenic diaphragm preparations, pulmonary arterial smooth muscle and even lung parenchyma. Other smooth muscle preparations that are used in organ bath research are urinary bladder, penile muscle strips and prostate.
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Organ Bath Systems

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Organ Bath System - 720MO

This Organ Bath System is ideal for work requiring a higher throughput, such as drug screening, running concentration response curves or in experiments where separation of vessels in separate baths is necessary.
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Muscle Strip System - 820MS 

Ideal system for measuring mechanical properties of isolated muscle strips such as TA, Soleus, EDL and/or vascular reactivity of larger ring-mounted segments of vascular smooth muscle, trachea, bronchial, lung, gut, uterine, colon, veins etc.​
See more
WIRE MYOGRAPHY
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
Organ Bath System - 720MO
ORGAN BATH
​Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
Organ Bath System - 720MO
​Muscle Strip System - 820MS
​​​PRESSURE MYOGRAPHY
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
MUSCLE STRIP
Muscle Strip System - 820MS
MyoDynamics Muscle Strip System - 840MD
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  • Products
    • Wire Myograph Systems >
      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Pressure Myograph Systems >
      • Pressure Myography
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
    • Organ Bath Systems >
      • Organ Bath
      • Organ Bath System - 720MO
      • Muscle Strip System - 820MS
    • Muscle Strip Systems >
      • Muscle Strip Systems
      • Muscle Strip System - 820MS
      • MyoDynamics Muscle Strip System - 840MD
    • Accessories >
      • Buffer Filler System
      • FlowMeter - 162FM
      • Software >
        • For Wire Myograph Systems
        • For Pressure Myograph Systems
      • Stimulators >
        • Stimulator - CS4/CS8
        • Stimulator - CS4+
  • Resources
    • Blog
    • Myograph Training
    • Service & Development
    • Software Downloads >
      • DMT Device Enabler
      • DMT MyoVIEW 5
  • About us
  • Contact