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​Dual-Channel Wire Myograph System - 420A

  • Ideal For Functional Studies Of Small Arteries
  • High Resolution And Precise Force Transducers
  • Direct Data Streaming to LabChart by ADInstruments
  • Modern & Today's Technology
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WATCH TRAINING VIDEO
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High Quality

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Thoughtful Design

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Latest Technology

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User Friendly

The Dual Wire Myograph System allows you to examine vascular reactivity and functional responses on small isolated arteries. Model 420A is ideal for testing two vessels with diameters of 30 μm simultaneously - 3 mm, independently. The vessels are mounted as ring preparations by threading them over two parallel wires and securing the wires to two supports or “jaws.” One support is attached to a precision micrometer, allowing manual control of vessel circumference and stretch. The other support is attached to a force transducer for the measurement of force/tension development.

The base of the chamber contains glass windows allowing morphological observations or fluorescence measurements on an inverted microscope. Typically, the preparation is kept in the heated vessel chamber in a physiological salt solution at 37°C, bubbled with oxygen where the vessels remain viable for at least 12 hours
The preparation is mounted in a heated 10 ml acid-resistant stainless steel chamber, which can be covered with a lid with ports for rapid suction/draining, refilling, and bubbling of oxygen supply. Following mounting and equilibration, the passive length-tension relationship of the vessel is determined. During the actual experiment, the circumference of the vessel is kept constant. Compounds can be added directly to the chamber, and the vessel’s contractility and reactivity are measured under isometric conditions.

In the Dual Wire Myograph System - 420A, the chamber can be divided for independent testing of each vessel. The two vessels also can be mounted in a single chamber by removing the divider. This allows direct comparative studies of vessels from treated/untreated conditions or diseased vs. healthy patient samples, for example, by exposing the vessels to identical concentrations of drug or compound. It is thus possible to examine whether a given pathological state is associated with altered morphology or reactivity.
As an option, an electronic valve can be added to the system for easy control and emptying of the chamber. The Wire Interface with a touch screen makes it easy to set up and use.

Furthermore, the Wire Interface is compatible with the DMT Device Enabler allowing automatic recognition of supported devices by LabChart, use of multiple devices simultaneously, and simultaneous recording of data into LabChart. 


Related Products ​​​​
  • Computer Package 
  • Data Acquisition  
  • Dissection Stereo Microscope
  • Dissection Tool Kit
  • Extended warranty years *1
  • Electronic Valve for buffer drainage
  • Field Stimulation Electrodes
  • Gas supply manifold - 4-channel 
  • Light Source LED​
  • Open Heating Bath Circulator 
  • pH electrode  & pH Meter
  • Service & Maintenance Agreement​
  • ​Stimulator
  • Tungsten Wire (25µm, 15µm, or 10μm)
  • Vacuum Package

*1 2-Years of warranty included in purchase
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Wire Myograph Chamber

​# Ring-mounted segments - 30µm to 3mm
# Fine scale micrometer for accurate tension control
# Force range ±200mN 
# Acid resistent stainless steel chamber 
# Optical base window for imaging

Interface Unit

# Direct data streaming
# Integrated heat control
# Intregreted calibration procedure
# ​Intuitive touch-screen menus
# Compact design / small footprint
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Data Sheet

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Citations Google Scholar

WIRE MYOGRAPHY
​Single Wire Myograph System - 320A
Confocal Wire Myograph System - 360CW
​Dual Chamber Wire Myograph System - 420A
Multi Myograph System - 620M
Automated Multi Myograph System - 630MA
​​​PRESSURE MYOGRAPHY
Pressure Myograph System - 112PP
Pressure Myograph System - 114P
Pressure Myograph System - 114PB
​​ORGAN BATH
​Organ Bath System - 820MO
​
MUSCLE STRIP
MyoDynamics Muscle Strip System - 840MD
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  • Products
    • Wire Myograph Systems >
      • Wire Myography
      • Single Wire Myograph System - 320A
      • Confocal Wire Myograph System - 360CW
      • Dual Wire Myograph System - 420A
      • Multi Myograph System - 620M
      • Automated Multi Myograph System - 630MA
    • Pressure Myograph Systems >
      • Pressure Myography
      • Pressure Pulsation Myograph System - 112PP
      • Pressure Myograph System - 114P
      • Pressure Myograph System - 114PB
    • Organ Bath Systems >
      • Organ Bath
      • Organ Bath System - 820MO
    • Muscle Strip Systems >
      • Muscle Strip Systems
      • MyoDynamics Muscle Strip System - 840MD
    • Accessories & Spare Parts >
      • Accessories
      • Buffer Filler System
      • Dissection & Mounting
      • FlowMeter - 162FM
      • Software >
        • For Wire Myograph Systems
        • For Pressure Myograph Systems
      • Stimulators >
        • Stimulator - CS4+
        • Stimulator - CS8
      • Transducers
  • Resources
    • Guides, Videos & More
    • Myograph Training/Installation
    • System Maintenance
    • Software Downloads >
      • DMT Device Enabler
      • DMT MyoVIEW 5
      • DMT MyoNORM
  • Blog
  • About us
  • Contact