Designed for large vessels
Mount arteries, veins and other vessel segments with internal diameters from 1.5 to 6.0 mm.
Pressure Myograph System – 110PXL
Pressure myography for large arteries and other large vessel segments
The DMT 110PXL is a pressure myograph for studying the physiological function and properties of large arteries, veins and other larger vessel segments under controlled pressurized conditions. It supports large-vessel reactivity, compliance, myogenic response and pharmacological studies where diameter changes are measured under precisely controlled transmural pressure.
1.5–6.0 mm
Large-vessel internal diameter range.
3.0–33.0 mm
Supported vessel segment length.
MyoVIEW ready
Live vessel tracking and pressure-myograph analysis.
110PXL
Large-vessel pressure myography
Why choose 110PXL
Purpose-built pressure myography for larger vessel preparations
The 110PXL is designed for laboratories that need robust pressure control, a large chamber and low-power optical access for pressurized arteries, veins and other vessels that are too large for standard small-vessel pressure myographs.
Controlled transmural pressure
In-line pressure transducers monitor and support controlled pressure close to the mounted vessel.
Large optical base window
Visualize larger vessel segments using low-power objectives and live camera-based diameter tracking.
Integrated chamber heating
Maintain stable chamber temperature without depending on continuous superfusion for heating.
XYZ vessel alignment
Adjust cannula position in three axes for controlled mounting and alignment of large vessel segments.
Acid-resistant stainless steel
Support routine cleaning while reducing adhesion of lipids and compounds to the chamber surface.
System overview
Large-vessel function under controlled physiological pressure
A large intact artery, vein or other vessel segment is mounted between two large-vessel supports and pressurized to the required transmural pressure. The vessel remains in its tubular geometry while diameter and wall parameters are tracked during pressure, reactivity or pharmacological protocols.
The chamber combines larger mounting adapters, integrated heating, in-line pressure measurement, a large optical window and XYZ positioning for controlled vessel alignment.
Large-vessel mounts
Accommodate vessels with internal diameters from 1.5 to 6.0 mm.
Controlled pressure
Apply and monitor transmural pressure from 0 to 250 mmHg.
Integrated heating
Maintain chamber conditions across a temperature range of
15.0 to 50.0 °C.
Low-power imaging
Use the large optical base window for continuous visualization
and diameter tracking.
Pressure Interface
Control pressure, temperature, calibration and system data from
the touch-screen interface.
System components
Chamber and interface for the complete pressure workflow
The 110PXL workflow combines the large-vessel chamber with a pressure-control interface and MyoVIEW software for live acquisition and vessel tracking.
110PXL large-vessel chamber
Acid-resistant stainless-steel chamber with a large optical window, large-vessel mounts, XYZ alignment, integrated heating and in-line pressure transducers.
Pressure Interface
Interface unit supporting pressure calibration, heat control, closed pressure-circuit operation, touch-screen menus, USB data communication and analogue outputs.
Research applications
Large-artery reactivity, compliance and pharmacology
The 110PXL is used where the dimensions of the vessel make standard small-vessel pressure myographs unsuitable and where diameter change under controlled pressure is the primary endpoint.
01
Large-vessel reactivity
Measure diameter changes in response to vasoactive compounds applied to the chamber or luminal solution.
02
Vascular compliance
Examine pressure-dependent diameter changes and large-vessel behavior under defined transmural pressure.
03
Myogenic response
Study intrinsic vessel responses during controlled pressure steps and pressure-dependent protocols.
04
Pharmacological testing
Evaluate large-vessel responses to agents applied to the superfusate or luminal solution.
05
Disease and remodeling studies
Compare large-vessel function in hypertension, atherosclerosis, ageing and other vascular disease models.
MyoVIEW workflow
Live diameter tracking and pressure-myograph analysis
MyoVIEW supports live vessel visualization, pressure control, temperature control, event marking and acquisition of vessel dimensions throughout the experiment.
The software can collect vessel and lumen diameter, wall thickness, intravascular pressure and derived vascular parameters during pressure, compliance and pharmacological protocols.
Live vessel detection
Track diameter changes continuously during pressurized vessel
experiments.
Multiple scanlines
Use multiple edge-detection zones to support robust vessel
measurements.
Experimental markers
Mark compounds, pressure steps and protocol interventions
during data acquisition.
Calculated parameters
Review diameter, wall thickness, cross-sectional area and
related pressure-myograph outputs.
Technical data
Key 110PXL specifications
Core chamber, vessel, temperature, pressure and communication specifications for evaluating the 110PXL.
Confirm vessel size, objective magnification, camera pathway,
pressure circuit, mounting requirements and training needs before
ordering.
Chamber
- Number of chambers
- 1
- Chamber volume
- 8.0–20.0 mL
- Chamber material
- Acid-resistant stainless steel
- Mounting type
- Cannulas / large-vessel mounts
- Vessel alignment
- X, Y and Z
- Micrometer resolution
- 0.01 mm
Vessel range
- Internal diameter
- 1.5–6.0 mm
- Vessel length
- 3.0–33.0 mm
Temperature
- Temperature range
- 15.0–50.0 °C
- Resolution
- 0.1 °C
- Stability
- ±0.2 °C
- Integrated heating
- Yes
Pressure
- Output reading
- mmHg
- Pressure range
- 0–250 mmHg
- Pressure stability
- ±0.5 mmHg
- Pressure resolution
- 0.1 mmHg
Reservoir
- Reservoir
- Heated
- Capacity
- 250 mL
- Pressure circuit
- Closed
- Air inlet
- 1 bar maximum
Output
- Data communication
- USB 2.0
- Analogue output channels
- 4
- Analogue output range
- ±2.5 V
Configuration guidance
Plan the complete large-vessel pressure-myography setup
The appropriate configuration depends on vessel dimensions, imaging requirements, pressure-circuit design, microscope and camera compatibility, mounting accessories and laboratory training needs.
Need-to-have items
Typical workflows include MyoVIEW acquisition, a suitable computer, inverted microscope, camera, stage micrometer, vacuum package, heating circulator, dissection microscope and dissection tools.
Imaging and mounting
Confirm low-power objectives, camera pathway, vessel-mount dimensions, cannula sizes, suture and pressure-circuit tubing.
Training and support
Consider installation, vessel mounting training, pressure calibration guidance, spare transducers and service coverage for high-use laboratories.
Frequently asked questions
Common questions about the 110PXL
What is the Pressure Myograph System 110PXL used for?
The 110PXL is designed to study the function and mechanics of large arteries and veins under controlled physiological pressure. It allows researchers to measure vessel diameter, compliance, vascular reactivity, and pressure-dependent responses while maintaining the vessel's natural tubular structure.
What types of blood vessels can be studied with the 110PXL?
The 110PXL is optimized for large arteries, veins, and other tubular tissues with internal diameters from approximately 1.5 to 6.0 mm. It's ideal for studies where vessel size exceeds the range of traditional small-vessel pressure myographs.
What measurements can the Pressure Myograph System 110PXL perform?
The system measures vessel diameter, wall thickness, compliance, vascular reactivity, intravascular pressure, and pressure-dependent changes in vessel function. Using MyoVIEW software, researchers can also calculate additional vascular parameters in real time.
Can the 110PXL be used to study arterial stiffness and vascular compliance?
Yes. The 110PXL is specifically designed for arterial stiffness, vascular compliance, and pressure-diameter studies. It enables researchers to investigate how large blood vessels respond to physiological pressure changes, disease, and pharmacological treatments.
Why choose a Pressure Myograph instead of a Wire Myograph for large vessels?
A Pressure Myograph preserves the vessel as an intact, pressurized tube, allowing researchers to study diameter changes, compliance, and myogenic responses under near-physiological conditions. A Wire Myograph measures force in ring-mounted vessels and is better suited for isometric contractility studies.
What research applications is the 110PXL best suited for?
The 110PXL is widely used in vascular physiology, hypertension research, cardiovascular disease, vascular remodeling, arterial stiffness, pharmacology, and translational vascular research where large vessel function is a primary endpoint.
What's the difference between the 110PXL and the 114P Pressure Myograph?
The 110PXL is designed for large arteries and veins (1.5–6.0 mm), making it ideal for large-vessel compliance and reactivity studies. The 114P is optimized for small arteries and resistance vessels where myogenic tone, flow-mediated dilation, and microvascular function are the primary research focus.
Is the Pressure Myograph System 110PXL the right system for my research?
The 110PXL is the ideal choice if your research focuses on large artery or vein physiology, vascular compliance, arterial stiffness, or pressure-dependent vessel behavior. If you're studying small resistance arteries or the microcirculation, a system like the DMT 114P may be a better fit.
Resources
110PXL documentation and supporting resources
Use the official product documents and DMT support resources when evaluating, installing or operating the 110PXL.
110PXL product data sheet
Product overview, applications, specifications and configuration guidance.
→110PXL user manual
Detailed system setup, pressure circuit, interface and calibration documentation.
→110PXL user guide
Practical guidance for vessel mounting and routine system use.
→MyoVIEW software
Live vessel tracking and analysis for pressure-myograph workflows.
→Pressure myograph systems
Compare the complete DMT pressure-myograph product family.
→Pressure comparison chart
Compare vessel size, pressure, flow, force and imaging capability.
→Pressure how-to videos
Review pressure calibration, leak checks and maintenance guidance.
→Training and installation
Plan setup, vessel mounting, pressure calibration and user onboarding.
→
Configuration guidance
Planning a large-vessel pressure-myography workflow?
Share the vessel type, expected internal diameter and segment length, pressure range, microscope and camera setup, objective requirements, mounting accessories and preferred analysis workflow. DMT can help define the appropriate 110PXL configuration.