 The Vessels of Survival: Dr. Johanna Hannan on Healing the Body After Cancer When it comes to understanding how blood vessels adapt, heal, and sometimes fail, few researchers bring as much insight and passion as Dr. Johanna Hannan, Associate Professor of Urology at the School of Medicine and Public Health at the University of Wisconsin–Madison. Her work explores the intricate vascular systems that supply vital organs—particularly the bladder, erectile tissue, and other pelvic structures—and how these systems are affected by disease, aging, and cancer treatments.
Dr. Hannan’s journey into vascular research began at Queen’s University in Canada, where she first used DMT myograph systems under the guidance of Dr. Michael Adams. That early experience sparked a fascination with how blood vessels respond to injury and stress—an interest that continues to shape her research today. Currently, Dr. Hannan and her team are investigating the long-term impact of radiation therapy on pelvic and prostate cancer survivors, as well as similar effects in women’s health. Their work focuses on targeting specific pelvic organs to better understand the lasting impact of treatment on vascular and smooth muscle function. Soon, they’ll have access to patient-derived tissue samples, bringing their studies even closer to clinical application. When asked about unexpected findings, Dr. Hannan recalled her graduate research on penile feed arteries and the challenges of studying injured vessels. Using spontaneously hypertensive rats, her team uncovered striking evidence of age-related vascular remodeling primarily in the penile feed arteries—and in models of chronic kidney disease, even calcification of penile blood vessels. These insights have helped connect the dots between systemic illnesses and local vascular changes. For Dr. Hannan, the DMT myograph systems remain central to this work. With two 620M wire myographs and two 820MO organ bath setups in her lab, her team can efficiently generate large volumes of data. “The DMT systems let us ask and answer questions quickly,” she said. “They make it possible to study molecular responses in great detail, especially when using pharmacological agents or other interventions.” While her research continues to produce important findings, Dr. Hannan finds her greatest fulfillment in mentorship and training. “What brings me the most joy,” she said, “is seeing students grow into independent researchers or go on to medical school. Watching them present their work at conferences—especially as podium presenters—is incredibly rewarding. I feel like I’m helping shape the next generation of scientists.” When asked about the challenges she’s faced along the way, Dr. Hannan was candid about the realities of navigating academia as a woman in science. She acknowledged that at times, it meant having to prove herself more than others or finding her voice in male-dominated spaces. Yet, she sees those experiences as part of what shaped her resilience and leadership style. “It’s important to recognize your worth and keep pushing forward,” she said. “Those moments make you stronger and help you advocate for the next generation coming up behind you.” Her advice to young researchers carries that same message of courage and growth: “Don’t avoid the hard tasks or the things that make you uncomfortable. That’s often where the biggest discoveries come from. Don’t let insecurities stop you—growth comes from pushing through the challenges.” Through her commitment to both science and mentorship, Dr. Johanna Hannan exemplifies the resilience she studies. Her work continues to uncover how vessels adapt and endure—illuminating not only the biology of survivorship but also the human spirit that drives scientific discovery forward.  In this "How To" video, you will be learning about the MyoVIEW software, exploring its data analysis features and navigating through the different options and menu selections.
Watch Here: MyoVIEW Introduction For more videos like this, check out out YouTube page and subscribe!  🎥 Wire Myograph vs. Organ Bath — Which is Right for Your Research?
In our latest comparison video, we take a closer look at how DMT systems differ — from vessel size and mounting options to chamber volume and experimental precision. The 620M Wire Myograph features jaw and pin mounts designed for small resistance arteries, offering precise control in a low-volume chamber for high-sensitivity measurements. The 820MO Organ Bath, on the other hand, accommodates pins, hooks and or clamps making it ideal for larger vessels and experiments that benefit from a larger chamber volume. Whether you prioritize microvessel accuracy or flexibility for larger tissue segments, this video highlights which system best fits your workflow. 👉 Watch now to see both systems in action: Wire vs Organ Bath #VascularResearch #Myograph #OrganBath #DMT #Physiology #ResearchTools #LabInnovation  Last week, we had an exciting install and training session at the University of Wisconsin-Madison, where we set up 2 wire myograph systems to support research in vascular and smooth muscle function.
Working alongside Johanna Hannan & Acacia White, PhD was a real highlight— their expertise and curiosity made the setup and training a smooth, collaborative process. The UW–Madison team will use the wire systems for rat artery and bladder tissue experiments, advancing our understanding of how blood vessels and smooth muscle work. Insights from this type of research can have an impact on conditions ranging from cardiovascular disease to bladder dysfunction. Learn more: Wire Myograph System - 620M #ResearchTools #LifeSciences #wiremyography #UniversityofWisconsinMadison  MyoVIEW provides a comprehensive platform for studying the pressure–diameter relationship in small arteries with precision and reproducibility.
Key Features: ✅ High-resolution lumen tracking via edge detection in up to four user-defined zones, ensuring accurate diameter averaging ✅ Quantification of wall structure, wall stress, strain, and myogenic tone for detailed assessment of vascular mechanics ✅ Real-time evaluation of vascular responses to pressure, flow, and pharmacological agents ✅ Integrated data acquisition, advanced calculations, and customizable live traces (e.g., instant strain computation through user-defined scripts) ✅ Fully adaptable workspace for optimal experimental control, visualization, and data management Optimized for use with pressure myograph systems, MyoVIEW streamlines complex pressure–diameter experiments, providing reliable insights into vascular reactivity and biomechanical function. 👉 Learn more about incorporating MyoVIEW into your pressure myograph workflow: MyoVIEW  The 112PP Pulsatile Pressure System is changing the game for small vessel studies by introducing controlled, physiologically relevant pulsatile flow.
From arterial stiffness to endothelial function, this system simulates real-life vascular conditions — and when paired with the DMT MyoVIEW software, researchers gain a powerful, integrated solution for real-time data acquisition, control, and analysis. 🔬 Fully compatible with pressure and wire myograph setups 💻 Seamless integration with MyoVIEW for streamlined workflows 📊 Realistic pressure profiles with unmatched reproducibility Take your cardiovascular research to the next level with precision you can trust! 👉 Learn more: https://www.dmt.dk/pressure-pulsation-myograph-112pp.html #CardiovascularResearch #VascularBiology #Myograph #LabTech #PulsatileFlow #DMT #MyoVIEW #ScienceTools  🚀 New Video Series Launch! We're excited to kick off our System Comparison Series
Whether you're a seasoned vascular researcher or just diving into wire or pressure myography, this series will break down the similarities and differences between our varying systems. 🔬 Expect clear comparisons, application tips and help choosing the right system for your lab! 👉 Check out our 112PP vs 114P video now: https://youtu.be/uWUbEo-bAwQ #DMTMyograph #VascularResearch #LifeScienceTools #LabTech  In the heart of Rotterdam, inside the renowned Erasmus University Medical Center, Professor Jan Danser leads one of Europe’s most innovative pharmacology labs focused on vascular biology and translational research. With a career spanning decades and an ever-evolving portfolio of high-impact publications, Prof. Danser is not just a professor—he’s a mentor, a visionary, and a relentless investigator of human cardiovascular physiology.
A Lab Like No Other... What makes Prof. Danser’s lab stand out is its impressive infrastructure and intense research throughput. Housing over 15 PhD students, the lab runs two full in-vitro experiments daily, utilizing 40 different baths. Their systems include multiple 1-, 2- and 4-channel systems. Each setup is used to its full potential, and every student is extensively trained before operating the systems—ensuring precision and reproducibility in every assay. “At this level, reliability is not optional - it’s essential,” notes PhD candidate Madhavi Harhangi, who has spent three years in the lab. “We’re working with very special tissues - human arteries and vessels that no one else in the world has access to. We need equipment that gives us results we can trust.” Human Tissue, Real-Time Research What sets the Danser lab apart is its direct access to rare, high-quality human tissues. Through an exclusive partnership with a Dutch hospital, the lab receives fresh vessel samples - including coronary arteries and placental arteries from mothers with a history of drug addiction - delivered via courier, sometimes in the middle of the night. A dedicated team member is always on call to receive these samples and ensure proper storage and preparation, no matter when the tissue is delivered. “Isolating vessels is key,” says Harhangi. “We isolate umbilical cord arteries from placentas exposed to addictive substances during pregnancy. These tissues allow us to study how drugs impact fetal development - a line of research no one else is currently pursuing.” Accessing and publishing research on these unique samples requires special ethical approval and patient consent. Prof. Danser emphasizes the importance of proactivity in sourcing quality vessels, a philosophy that underpins the lab’s success in pioneering research on sFlt-1, VEGF inhibitors, and preeclampsia-related mechanisms. The Pressure to Publish... and Excel... Prof. Danser holds his students to a rigorous academic standard. Each PhD candidate is expected to publish four scientific papers within four years. This goal is not merely academic - it’s a reflection of the lab’s intense daily workflow, strategic planning, and a research culture built around continuous training and scientific excellence. With such high expectations, every element in the lab - from technique to technology - must perform at the highest level. The team transitioned from DMT’s 2-channel 410A systems to the more advanced 4-channel 620M, allowing them to scale up experiments and reduce turnaround time. Why DMT? Trust and Precision... For Prof. Danser and his students, DMT’s systems are more than just tools - they are the foundation of reliable science. “The accuracy and consistency of DMT equipment are unmatched,” says Harhangi. “When you’re working with tissue this rare and data this valuable, you can’t afford to question your setup.” As the lab continues to break new ground in the field of human vascular pharmacology—whether through antibody-based treatments, receptor analysis, or translational studies in preeclampsia - one thing is clear... excellence is not an accident in the Danser lab. It’s engineered every single day.  🧪 Does size matter? When it comes to your lab bench — absolutely!
The DMT Organ Bath System - 820MO delivers the full functionality of a traditional organ bath system, but with a much smaller footprint. Designed for efficiency and precision, it frees up valuable space without compromising on performance. Whether you're running pharmacological or physiological studies, the 820MO proves that less can truly be more! 🔬 Compact. Reliable. Versatile. Upgrade your lab without upsizing your setup: 820MO #OrganBath #Pharmacology #Physiology #LabInnovation #DMT #BiomedicalResearch  🚨 Release: Organ Bath System 751mT (mini-TOBS) 🚨
We’re excited to introduce the Tissue Organ Bath System - 751mT mini-TOBS — a compact, affordable, and smart solution built for budget-conscious research environments. 💡 Whether you're studying cardiac, skeletal, or smooth muscle, the mini-TOBS delivers: - Isometric or isotonic contractile force measurement - Fast air-based heating (no water system!) - Automated filling/emptying - Easy integration with external data acquisition - Low-maintenance design – part swaps in under a minute - Two heated/aerated buffer bottles for flexibility - Fume hood–friendly for work with hazardous tissue Borrowing core tech from our high-end myograph systems, the mini-TOBS raises the bar for versatility, performance, and ease of use in physiology, pharmacology, and toxicology education. 🔬 Learn more about how the mini-TOBS can elevate your lab experience: 751mT #Physiology #Pharmacology #TissueOrganBath #LabInnovation  🔬 Installation Spotlight at the University of Arizona
We had the pleasure of installing the 112PP Pressure Myograph System in Dr. Liya Yin’s lab at the University of Arizona. 🎓 Dr. Yin’s research focuses on Coronary Microvascular Dysfunction in Diabetic Cardiomyopathy — a critical area in cardiovascular science aimed at understanding how diabetes impacts coronary microvascular health and cardiac function. With the 112PP system, her lab will be equipped to explore small vessel structure and function under near-physiological conditions, enabling high-resolution insights into vascular dynamics. A big thank you to Dr. Yin and her team for their dedication to advancing microvascular research — we're proud to be a part of it! 💡 Looking to elevate your vascular studies? Discover how our pressure myograph systems can support your research goals: See More #PressureMyograph #Microcirculation #CardiovascularResearch #DiabeticCardiomyopathy #CoronaryMicrovascularDysfunction #VascularBiology #LifeSciences
Great Customer Visit, Great Feedback!
Our Product Specialist, Aaron Stupica just had the pleasure of visiting Prof. Roshanak Rahimian at the University of the Pacific, CA, USA, and we're thrilled to share how pleased she was with the visit! Prof. Rahimian has been using our DMT Myograph System in her vascular research, and it was incredibly rewarding to hear how the pressure myograph continues to support her groundbreaking work. Her enthusiasm and feedback reaffirm myograph systems impact in advancing scientific discovery. At DMT, we're proud to support researchers like Prof. Rahimian who are pushing the boundaries of knowledge. Thank you for your continued trust in our technology! #DMT #Myograph #OrganBath #CardioVascularResearch #IsolatedTissue  🔬 Revolutionize Your Pharmacology Studies with the DMT 820MO Organ Bath System 🧪
A modern alternative to traditional, bulky organ bath systems. The 820MO is designed with a significantly smaller footprint, making it ideal for labs where space is at a premium—without sacrificing performance. Whether you're conducting classic isometric contraction studies or testing drug efficacy on smooth, skeletal, or cardiac muscle, the 820MO delivers precision and reliability. ✅ Compact design for streamlined lab integration ✅ Highly versatile — supports a wide range of tissue types and experimental needs ✅ Intuitive control and data acquisition via MyoDAQ 🔗 Learn more: [ https://www.dmt.dk/organ-bath-820mo.html ] #Pharmacology #OrganBath #LabInnovation #SmoothMuscleResearch #TissueStudies #PreclinicalResearch #LifeSciences  🔬 Exciting News! DMT will be sponsoring and attending #ESM2025!
We’re proud to support and join the vibrant international microcirculation research community. 💡 Join us to: ✅ Explore cutting-edge research ✅ Connect with leading scientists ✅ Support new solutions in vascular biology ✅ Celebrate the future of therapeutic technologies 📅 We can't wait to see you there! #Microcirculation #VascularResearch #LifeSciences #ScientificCollaboration #BiomedicalInnovation  🔍 Tired of sifting through hours of data to find what really matters?
Say hello to smarter analysis with the MyoDAQ Data Selection Feature. Whether you're isolating isometric plateaus, identifying peak twitch responses, or narrowing down your data to the most relevant time windows — MyoDAQ makes it intuitive. 🧠💡 With just a few clicks, you can select, zoom, and export the exact segments you need for clearer insights and faster results. ✅ Streamlined workflow ✅ Precise data targeting ✅ No more guesswork ✅ Unlimited data selections added with just a single click If you're working with muscle physiology or vascular function data, this feature isn't just convenient — it's essential. 🔗 To learn more about the MyoDAQ Data Acquisition software and how it’s transforming the way researchers handle data, click here #MuscleResearch #PhysiologyTools #MyoDAQ #DMTMyograph #LifeSciences #LabInnovation #DataAnalysisMadeEasy  Day 1 at the American Physiology Summit 2025 is off to a fantastic start!
It’s been so great seeing familiar faces, meeting new ones, and connecting with the amazing community pushing science forward. If you haven’t stopped by yet, come visit us at booth #1114 — we’re ready to talk all things research! 🔬✨ Thank you American Physiological Society for having us - Let’s keep the momentum going! #APS2025 #Myography #ScientificCommunity #ResearchConnections Dr. Eric Belin de Chantemele: Advancing Cardiovascular Research with a Focus on Women’s Health4/17/2025
 Dr. Eric Belin de Chantemele, a Professor of Medicine at the Vascular Biology Center at Augusta University, has dedicated his research to understanding the complex relationship between obesity, hypertension, and cardiovascular disease, particularly in women. His work explores how lipid deficiency and lipo-dystrophy in mice impact vascular function, with a specific focus on how the absence of fat affects cardiac health. Interestingly, his initial research was inspired by studying the effects of spaceflight on cardiac disease in mice, which eventually led him to uncover critical insights about obesity-related hypertension.
One of Dr. Belin de Chantemele’s most surprising discoveries came while working with a mouse model deficient in alpha-1B receptors. When he ran out of male mice and had to shift focus to female mice, he discovered that female mice displayed worse vascular function. This finding was unexpected but he believed in the data, which led to his groundbreaking research on leptin, a hormone that regulates estrogen—resulting in his most cited paper to date. His research holds immense promise for the future, with the ultimate goal of developing targeted treatments for cardiovascular disease in women. Dr. Belin de Chantemele hopes that his work will lead to more personalized therapies that address the unique cardiovascular challenges faced by women, closing the gap in treatment outcomes. A long-time user of DMT equipment from his postdoc in France, Dr. Belin de Chantemele praises the reliability and ease of use of the systems, noting that his lab operates seven DMT wire systems daily. This dependable technology has been instrumental in facilitating his research and ensuring consistent results. When reflecting on his career, Dr. Belin de Chantemele is most proud of the impact he’s had on the next generation of researchers. Many of his trainees have transitioned to faculty positions, received prestigious awards, and, in 2024 alone, three of his students were awarded fellowships while another three secured R01 grants. Like many in his field, Dr. Belin de Chantemele faced significant challenges early in his career, particularly in securing his first R01 grant, which took three submission cycles to obtain. His advice to aspiring researchers is simple yet powerful: “Be persistent, believe in your data, and don’t be afraid to fail.” Through his commitment to research, mentorship, and innovation, Dr. Belin de Chantemele continues to shape the scientific community and pave the way for future breakthroughs in cardiovascular health.  🔧 New Video Alert! 🎥
Need to change a force transducer on a 630MA? We've got you covered! Our latest YouTube video walks you through the process step by step, making it easy to keep your setup running smoothly. Watch now and ensure your experiments stay precise and reliable! ⬇️ 📺 Watch Now: https://youtu.be/zrWNE8Dvvz4 #LabTech #ForceTransducer #HowTo #DMT  We had the opportunity to conduct a hands-on training and install of the 620M Wire Myograph System with a Vacuum Package with Nicha Boonpattrawong.
Dr. Boonpattrawong's impressive journey spans from earning her degree at the University of Toronto to groundbreaking research in cardiometabolic disease and ovarian cancer at BC Children’s Hospital and UW-Madison. Now, as she launches her own research program in metabolic physiology of cancers and metabolic diseases, our DMT equipment will play a key role in helping her characterize metabolic reprogramming in disease models and identify potential treatment targets. We’re excited to support her innovative research and look forward to seeing the incredible discoveries ahead! 💡  We are thrilled to be a Specialty Sponsor at the 2025 NAA Conference, taking place on June 27-28 in Philadelphia, Pennsylvania!
 We just released a step-by-step MyoVIEW tutorial to help you streamline your workflow and ensure precision every time. Whether you're new to MyoVIEW or just need a quick refresher, this video has you covered!
📺 Watch now: https://youtu.be/COpj_mEN-Xk Let us know what you think in the comments! #Myoview #HowTo #LabEfficiency  We had the opportunity to conduct a hands-on training session of the 112PP Pressure Myograph System at Thiago Bruder's lab at the University of South Alabama.
Their research is focused on understanding how endothelium-derived molecules influence vascular remodeling in conditions such as hypertension and vasculitis. Using the 112PP system, they’re diving deep into exploring vascular function under physiological and pathological conditions. A big thank you to Thiago and the entire team for their enthusiasm and commitment to advancing vascular research. Looking to enhance your vascular research? Contact us to learn how our pressure myograph systems can support your work! See more... #VascularResearch #Hypertension #PressureMyograph #Endothelium #CardiovascularHealth #ResearchTraining #DMT  New Training Video Series Alert! 🎥
We’re excited to release the 112PP Pressure Myograph Training Video Series, designed to help you master every step of your vascular research journey! From setup to advanced techniques, these videos showcase how to get the most out of your 112PP system for groundbreaking discoveries. 💡 Whether you’re new to pressure myography or looking to refine your skills, this series is your go-to guide for precision and innovation. Ready to elevate your research? Check out the series now and let us know what you think! For more information: https://www.dmt.dk/pressure-pulsation-myograph-112pp.html #DMT #PressureMyograph #VascularResearch #TrainingMadeEasy #InnovationInScience  🎄✨ Happy Holidays from DMT! ✨🎄
Thank you for being part of our journey in advancing science. Here’s to a successful and innovative New Year! 🧪🎉  Last week, our Senior Scientific Product Specialist Larry Agbor, Ph.D, M.S had the opportunity to conduct a hands-on training session at the Rhian Touyz, MBBCh, PhD, FRCP, FRSE, FCAHS, FMedSci Laboratory at McGill University. The session provided researchers with in-depth guidance on maximizing the system’s capabilities to advance their vascular studies using the 114p pressure myograph system.
Thank you, McGill, for the warm welcome. We’re looking forward to seeing how this new knowledge and technology will fuel future discoveries! For more information, visit: https://www.dmt.dk/pressure-myograph-114p.html #Training #VascularResearch #CustomerSupport #McGillUniversity #ScientificInnovation |
