We had a wonderful visit with Benjamin Smood, MD at Penn Medicine, University of Pennsylvania Health System! Excited to share the successful installation of the 620M Wire Myograph paired with our Buffer Filler System. This state-of-the-art equipment will empower researchers and students to delve deeper into vascular physiology, advancing our understanding of cardiovascular health and disease. Kudos to our Sr Scientific Product Specialist, Larry Agbor, Ph.D, M.S for aiding in the installation!
#WireMyography #Research #CardiovascularScience #PennStateUniv We are pleased to announce the launch of our new proprietary data acquisition software, MyoDAQ! MyoDAQ offers a simplified data acquisition application intended for use with DMT wire myographs and organ bath systems. This software provides a streamlined, user friendly approach for data collection and analysis.
By highlighting only necessary features, researchers experience improved ease-of-use, better navigation and easier control for data analysis. To learn more about this software, visit https://www.dmt.dk/myodaq.html or contact a DMT representative! #dataanalysis #dataacquisition #wiremyography #organbath Having a great first day at The American Physiology Summit @APSPhysiology. We love seeing a lot of familiar faces and connecting with everyone. Make sure to stop by our booth (#520) and say hello. We look forward to seeing you! #APS2024 #WeArePhysiology
Just one week until the American Physiology Summit! We look forward to attending and connecting with you all there. Stop by our booth (#520) for the latest updates on our myograph systems and get a sneak peek of our new and simplified data acquisition software, developed explicitly for organ bath and myograph systems. See you soon!
#APS2024 In a few weeks, at the American Physiology Summit, stop by our booth (#520) and get a sneak peek of our new and simplified data acquisition software, developed explicitly for organ bath and myograph systems.
The Pressure Myograph System - 110PXL is used to measure large arteries, veins, and other vessels physiological function and properties. The 110PXL chamber, in combination with low-power objectives, can be used for the study of large artery reactivity and/or compliance by measuring diameter changes under physiological pressures, which are precisely controlled through the system interface.
The system comes with mounts of 1.5mm, 3mm, and 4mm for mounting vessels between 1.5-6.0mm. There is no force transducer on the standard chamber, but it can be added. This system is a great option for expanding pressure myograph capabilities! In this video, you will be learning about how to grease important mechanical parts on the Multi-Myograph System 620M.
Product Link: Multi-Myograph System 620M To learn more visit our Resources Page For more information visit us at www.dmt.dk or email sales@dmt.dk to speak to a representative. Introducing the 820XL chamber! This robust organ bath chamber offers myograph users a larger tissue capability while still maintaining the compact features of the organ bath interface.
Users will be able to work with rings larger than 500µm and strips up to 45mm in length, giving an ideal range for those experimenting with larger vessels. For more information on the 820XL Chamber, visit: https://www.dmt.dk/organ-bath-820mo.html We’re thrilled to release an updated version of MyoPULSE software for our current simulators. Packed with powerful features, enhanced performance and a new improved user experience, this release takes a big step forward.
Here’s some of the new features…
Interested in upgrading your current version of MyoPULSE - contact us APAC Scientific is showcasing DMT's latest Myograph and Organ Bath systems at the ASCEPT Annual Scientific Meeting, 20-23 November, 2023 in Sydney, Australia. DMT will be represented by China Gate Scientific (CGS) at the upcoming World Congress of Microcirculation, September 20-24, in Beijing, China.
Cutting-edge, innovative myograph systems will be on display, and the CGS team will be on hand to provide insights, answer questions and offer recommendations to enhance your vascular reactivity studies. We are happy to announce the NEW 114PB Pressure Myograph System! This cost effective system is able to provide consistent and reliable results for pressurized vessel studies only. Our Scientific Product Specialist, Aaron Stupica gives an in depth look of the simplified pressure system which can be found in the training video series!
DMT is excited to exhibit at the upcoming ESM meeting in Aarhus, Denmark. We'll be displaying the latest innovative systems and recently added pressure myograph chambers. Make sure to stop by our booth.
We are getting ready to attend the American Physiology Summit being held in Long Beach, CA April 20-24. Stop by and learn more about our new pressure myograph chambers.
Our Scientific Product Specialist, Aaron Stupica gives an in depth look of the DMT Automated Wire Myograph System. This 4-channel system allows the study of any tubular segment's vascular functionality while adding the feature of automated normalization procedures so calculations and preload tension are easily set. Click the links in the description to watch our full video training guides and get more in depth information on our myograph systems!
DMT is excited to exhibit at the European Muscle Conference in Prague, Czech Republic. You will find our Scientific Product Specialist, Dr. René Hummel at our booth – ready to show you the variety of our systems for muscle physiology research.
Announcing the DMT "How To" video series!
Ever wondered how you mount an artery on a DMT myograph system? Or how mounting supports are changed? Well...we have just released a series of "how to" videos that will teach you a variety of techniques and reference the use of DMT myograph systems. Make sure to subscribe to our YouTube page so you don't miss out on any new videos and content that we release! #DMT #Myograph Yes, it does...when it comes to efficiency and output in a research laboratory.
Gone are the days when the organ bath system took up an entire bench top. The DMT Organ Bath system is a compact and robust design, where the footprint is so much smaller that you can fit several systems within the footprint of the conventional organ bath. This allows you to save a tremendous amount of valuable lab space and maximize your throughput. Minimize your equipment footprint while maximizing results. For more information on the DMT Organ Bath System, check out our 820MO page! #DMT #DanishMyoTechnology #BasicResearch #OrganBath #IsolatedTissue Organ baths are a well-known, classic experimental setup commonly used for reactivity studies of ex vivo tissue preparations. With the introduction of the DMT Organ Bath – 820MO, we combine decades of knowledge from myography and conventional organ bath setups into a modern, state-of-the-art system that enhances productivity. The robust yet compact design adds value to users with built-in features such as oxygenation, buffer drainage, calibration procedures, and heating. It even has selectable force ranges for the type of tissue used. Interesting publication in which the DMT MyoDYNAMICS Muscle Strip System - 840MD were used. Read the full article at MDPI/biomedicines
We have RELAUNCHED the 420A Dual Chamber Wire Myograph System! This was one on the earliest Myographs released by DMT in the early 1980's and it has been updated and reintroduced. This is a perfect system for side by side vessel comparison studies, small working volume and reproducible and reliable experiments. The durability of the build and materials allow for heavy use and reproducible experiments. This system has been built for optimal performance which will last many years.
For more information about the 420A Dual Chamber Wire Myograph System, visit the 420A product page.
At the start of the 1980s, Dr Majid Sheykhzade was a hard-working, academically gifted teenager looking forward to university in Iran. His accolades included a front-page newspaper story that recognized him as a "super-student." However, the devastating Iran-Iraq War caused the closure of all universities, Dr Sheykhzade's options became extreme and lmited: military service or immigration. At the age of 20, Dr Sheykhzade made the difficult choice to leave.
Dr Sheykhzade arrived in Denmark by chance. The majority of his relatives relocated to California, USA. Dr Sheykhzade is grateful that Denmark became his new home: "Denmark is an amazing, unique country. I am pleased to be able to give back to the community that has welcomed me with so much support and opportunity." Links between the cardiovascular system and common diseases Today, as an Associate Professor in the Department of Drug Design and Pharmacology at the University of Copenhagen, Denmark, Dr Sheykhzade is a researcher and educator. His cutting-edge cardiovascular physiology and pharmacology research explores the complex mechanism behind the regulation of arterial tone in the cardiovascular system to understand its role in diseases such as diabetes, stroke, hypertension, congestive heart failure, migraine, and age-related changes. Dr Sheykhzade's research has been helped by a long-standing and fruitful collaboration with a range of researchers that includes Professor Lars Edvinsson, wo is the Director of the Glostrup Research Institute – Rigshospitalet and his team, as well as two of the Institute's key Senior Researchers: Dr Anette Sams and Dr Kristian Agmund Haanes. To date, Dr Sheykhzade has almost 100 papers published in peer-reviewed reputed international scientific journals (such as the British Journal of Pharmacology), as well as several book chapters. As an advocate for the importance of research, he is dedicated to nurturing the next generation of scientific leaders. He also plays a leadership role in the scientific community, providing his time to help advance scientific research and discovery. His community work includes presenter, organizer, and chair of scientific meetings, he is a full member of British Pharmacological Society (BPS), Scandinavian Physiological Society (SPS), and Danish Heart Association. The start of Dr Sheykhzade's career In the 1990s, Dr Sheykhzade's early tertiary education and work experience gave him an understanding and insight into science in the public and private sectors. He obtained a Masters MSc in Pharmacy from the Royal Danish School of Pharmacy, worked at Bispebjerg Hospital Pharmacy, the French pharmaceutical company IPSEN Scandinavia A/S and later in a medical department monitoring clinical trials. In 1996, his growing passion for scientific research led to a 4 year self-financing Ph.D. at the University of Copenhagen. He was able to apply for and attract grants, a skill that he still applies for emerging research. He studied under Prof. Niels Chresten Berg Nyborg, who "introduced me to the fascinating and interesting field of vascular physiology and pharmacology". How DMT Myograph systems fuelled Dr Sheykhzade's research Dr Sheykhzade started using DMT Myograph systems to control and study isolated organ activity and contraction. In addition to using tissue from various rodents, he has also used human subcutaneous resistance arteries. The extensive range of studies includes measuring intracellular calcium concentration using a single chamber myograph system and fluorescence microscopy. Dr Sheykhzade describes the DMT Myographs as fundamental to his research, "DMT myographs are everything to my work. I have succeeded in reaching important milestones in my studies on vascular tone in health and disease by using these robust, reliable organ baths. It happens often that scientific results published in well-reputed journals with high impact factors such as Nature are hardly reproducible by other investigators or laboratories. "My results using myographs are reproducible, it has been proven more than once." "One of the great advantages of the myograph setup is that it can be easily adapted or modified in order to answer many scientific questions. For example, it can be used for electrical field stimulation, placed on the stage of inverted microscope for measurement of intracellular calcium, and used for studying contractions in bladder smooth muscle strips." Experiments that develop critical thinking Dr Sheykhzade introduced the 4-channel wire myograph systems for studying in-vitro techniques in pharmacology to the Master's program. To date, he has supervised approximately 60 Master students as well as 15 PhD students. "I have used myographs in the teaching of both bachelor and Master students with great success. My students love to work with isolated arteries. They enthusiastically add compounds to the myograph baths, record the effects and perform the concentration-response curves. "The myography technique encourages students to be proactive and ask critical questions during experiments. My students become familiar with pitfalls and important tricks when conducting in-vitro experiments with isolated organs. They become skilled at interpreting data, making conclusions, and troubleshooting problems, "said Dr Sheykhzade. Dr Sheykhzade's commitment to teaching and helping new scientists has led to faculty awards and nominations, including two times winner of the best teacher of the year. Future directions in research and education Continuing his scientific endeavors, Dr Sheykhzade currently investigates 1) the role of calcitonin gene-related peptides in the pathophysiology of migraine and 2) the role of formyl peptide receptors (FPRs), toll-like receptors (TLR2 and TLR4) in the development of atherosclerosis. He also looks at vasomotor activity, calcium handling, and metabolism in arteries isolated from different vascular beds of type 2 diabetic mice and rats. Dr Sheykhzade plans to help set up Ph.D. and postdoc projects to conduct investigations on these research projects. "I am working to uncover the complex mechanism behind the inflammatory process that leads to vascular inflammation, atherosclerosis, and ischemia in diabetic patients, especially those with type II diabetes. The key players involved in this inflammatory process are indeed potential targets for drug intervention, and the information obtained from the study will hopefully help early diagnosis and improve the treatment of these patients. "My research at the University of Copenhagen continues to excite me, and DMT myographs are playing an important part. The myographs are cited in 95% of my publications, and there are many more papers ahead. I also want to keep helping young people to find their research passion. We still have many questions to answer." A SELECTION OF DR MAJID SHEYKHZADE'S RECENT PAPERS Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice. Beck L, Pinilla E, Arcanjo DDR, Hernanz R, Prat-Duran J, Petersen AG, Köhler R, Sheykhzade M, Comerma-Steffensen S, Simonsen U. Front Pharmacol. 2021 Jan 12;11:619152. doi: 10.3389/fphar.2020.619152. eCollection 2020. PMID: 33643042 Effect of increased potassium intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study. Dreier R, Abdolalizadeh B, Asferg CL, Hölmich LR, Buus NH, Forman JL, Andersen UB, Egfjord M, Sheykhzade M, Jeppesen JL. Nephrol Dial Transplant. 2020 Dec 6:gfaa292. doi: 10.1093/ndt/gfaa292. Online ahead of print. PMID: 33280043 Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice. Beck L, Su J, Comerma-Steffensen S, Pinilla E, Carlsson R, Hernanz R, Sheykhzade M, Danielsen CC, Simonsen U. Front Physiol. 2020 Jun 23;11:667. doi: 10.3389/fphys.2020.00667. eCollection 2020. PMID: 32655412 Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity. Zhu J, Pedersen MD, Ahmed LS, Abdolalizadeh B, Grell AS, Berg JO, Thulstrup PW, Franzyk H, Edvinsson L, Sams A, Sheykhzade M, Hansen PR. Int J Mol Sci. 2020 Feb 17;21(4):1343. doi: 10.3390/ijms21041343. PMID: 32079247. Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice. Arildsen L, Andersen JV, Waagepetersen HS, Nissen JBD, Sheykhzade M. Diab Vasc Dis Res. 2019 Nov;16(6):539-548. doi: 10.1177/1479164119865885. Epub 2019 Jul 31. PMID: 31364402 C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system. Edvinsson JCA, Warfvinge K, Krause DN, Blixt FW, Sheykhzade M, Edvinsson L, Haanes KA.J Headache Pain. 2019 Nov 12;20(1):105. doi: 10.1186/s10194-019-1055-3.PMID: 31718551 By Helen Inkson | Communications Manager |DMT-APAC |
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