TISSUE ORGAN BATH SYSTEMS - GENERAL
|
FEATURES & BENEFITS
|
"The addictive workhorse for your routine high-throughput pharmacological studies on nearly all type of muscle."
An isolated organ bath assay is the classical pharmacological screening tool to assess concentration-response relationships in contractile tissue. Although a variety of molecular tools have become available in recent decades to assess cellular responses in high-throughput quantities, the organ bath assay is still considered a valuable tool for lead optimization and for the elucidation of the mechanism of action. In addition, organ bath assays are widely used in preclinical safety studies. Find here all the different types of Tissue Organ Bath Systems.
The most common application of the organ bath assay is in cardiovascular research, using isolated aortic rings, heart tissue (papillary muscle, left ventricles) or arteries. For studying gastro-intestinal effects, preparations of ileum and colon are often used, but also gastric antral muscle and sphincter may be studied.
Respiratory effects can be studied in isolated tracheal rings, phrenic diaphragm preparations, pulmonary arterial smooth muscle and even lung parenchyma. Other smooth muscle preparations that are used in organ bath research are urinary bladder, penile muscle strips and prostate.
An isolated organ bath assay is the classical pharmacological screening tool to assess concentration-response relationships in contractile tissue. Although a variety of molecular tools have become available in recent decades to assess cellular responses in high-throughput quantities, the organ bath assay is still considered a valuable tool for lead optimization and for the elucidation of the mechanism of action. In addition, organ bath assays are widely used in preclinical safety studies. Find here all the different types of Tissue Organ Bath Systems.
The most common application of the organ bath assay is in cardiovascular research, using isolated aortic rings, heart tissue (papillary muscle, left ventricles) or arteries. For studying gastro-intestinal effects, preparations of ileum and colon are often used, but also gastric antral muscle and sphincter may be studied.
Respiratory effects can be studied in isolated tracheal rings, phrenic diaphragm preparations, pulmonary arterial smooth muscle and even lung parenchyma. Other smooth muscle preparations that are used in organ bath research are urinary bladder, penile muscle strips and prostate.
Paragraph. Klik her for at redigere.
Paragraph. Klik her for at redigere. / Paragraph. Klik her for at redigere.
- 1
- 2
- 3
- 4
- 5
I’m stunned at how easy it is to mount vessels, put them in the chambers, and make sure that we control the variables that we need to when doing experiments.
Dr. Stephanie Watts
Professor in Pharmacology & Toxicology / Michigan State University
- 1
- 2
- 3
- 4
- 5
ALL TISSUE ORGAN BATH SYSTEMS
Tissue Bath System - 720MO
State-of-the-art research instrument for the in vitro study of larger blood vessels (>500 μm) and other tubular tissues mounted as ring preparations of up to 10 mm in diameter, such as trachea or gut.
This Tissue Organ Bath System is an improved version of the 700MO system with a re-designed Myograph-Interface. The myograph system is ideal for work requiring a higher throughput, such as drug screening, running concentration response curves or in experiments where separation of vessels in separate baths is necessary.
To name a few improvements the 720MO system contains following changes:
• The heating has been made more accurate down to the individual bath level.
• The operation of the interface has been made even more intuitive and easy to handle. The front switches have been replaced by a graphical color touch-display.
Tissue Organ Bath System - 750TOBS
The 750TOBS has been used extensively to investigate the physiology and pharmacology of smooth muscle and other muscular tissue preparations.
Mini Tissue Organ Bath System - 751mT
An ideal student Tissue Organ Bath System, recommended for a large variety of studies, predominantly in the teaching environment.
State-of-the-art research instrument for the in vitro study of larger blood vessels (>500 μm) and other tubular tissues mounted as ring preparations of up to 10 mm in diameter, such as trachea or gut.
This Tissue Organ Bath System is an improved version of the 700MO system with a re-designed Myograph-Interface. The myograph system is ideal for work requiring a higher throughput, such as drug screening, running concentration response curves or in experiments where separation of vessels in separate baths is necessary.
To name a few improvements the 720MO system contains following changes:
• The heating has been made more accurate down to the individual bath level.
• The operation of the interface has been made even more intuitive and easy to handle. The front switches have been replaced by a graphical color touch-display.
Tissue Organ Bath System - 750TOBS
The 750TOBS has been used extensively to investigate the physiology and pharmacology of smooth muscle and other muscular tissue preparations.
Mini Tissue Organ Bath System - 751mT
An ideal student Tissue Organ Bath System, recommended for a large variety of studies, predominantly in the teaching environment.
RESEARCH VIDEO
"Analytical Techniques for Assaying Nitric Oxide Bioac-tivity" (720MO)
Hong Jiang, Deepa Parthasarathy, Ashley C. Torregrossa, Asad Mian, Nathan S. Bryan
Hong Jiang, Deepa Parthasarathy, Ashley C. Torregrossa, Asad Mian, Nathan S. Bryan
