SINGLE MYOGRAPH SYSTEM - 320A
FEATURES & BENEFITS
»base window allowing morphological or fluorescence measurements«
The Single Wire Myograph System - 320A is ideal for studying a single vessel with a diameter of 30 μm - 3 mm. The vessel is mounted as a ring preparation by threading it over two parallel stainless steel wires and securing the wires to two supports or "jaws". One support is attached to a precision micrometer, allowing manual control of vessel circumference and stretch. The other support is attached to a force transducer for measurements of force/tension development.
The preparation is mounted in a heated 10 ml acid-resistant, stainless steel chamber, which can be covered with a lid featuring ports for rapid suction/draining, refilling and bubbling of oxygen. The base of the chamber contains a window allowing morphological observation or fluorescence measurements on an inverted microscope. Typically, the preparation is kept in the heated vessel chamber in a physiological salt solution at 37°C, bubbled with oxygen where the vessels remain viable for at least 12 hours.
»for studying a single vessel with a diameter of 30 μm - 3 mm«
"Calcium oscillations in human mesenteric vascular smooth muscle"
Navarro-Dorado, Garcia-Alonso, van Breemen, Tejerina, Fameli
"TMEM16A knockdown abrogates two different Ca2+-activated Cl - currents and contractility of smooth muscle in rat mesenteric small arteries"
Dam VS, Boedtkjer DM, Nyvad J, Aalkjaer C, Matchkov V.