Organ Bath and Isolated Tissue Systems

Measure contractile function in isolated tissue preparations

DMT organ bath and tissue myograph systems support ex vivo studies of vascular, smooth, skeletal and cardiac tissue under controlled experimental conditions. Select the platform according to tissue geometry, preparation size, chamber volume, normalization needs, measurement endpoint and throughput.

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Small vessels to larger tissues Wire myograph, ring-mounted and strip-mounted preparations.

Controlled conditions Temperature, buffer, gassing and reproducible mounting.

1 or 4 channels Focused single-channel or parallel multi-channel workflows.

System selection Match tissue, endpoint and throughput to the right platform

What the systems measure

Functional responses from isolated vascular and muscular tissue

DMT tissue systems preserve preparation architecture and receptor context while allowing contractile responses to be measured under controlled laboratory conditions.

01

Isometric force

Measure contraction and relaxation while preparation length is held constant, supporting vascular and smooth muscle pharmacology.

02

Normalized vascular reactivity

Use the 620M for small vessel and tissue-ring studies where reproducible passive length-tension conditions are required.

03

Movement or stimulated response

Use compatible isotonic configurations, electrodes and stimulators where displacement or electrical stimulation is part of the protocol.

Typical applications

Ex vivo physiology, pharmacology and tissue function

These systems support studies where intact tissue response must be evaluated under defined buffer, temperature, gassing, preload and mounting conditions.

Platform selection depends on preparation geometry, expected force, chamber volume, normalization requirements and the number of samples studied in parallel.

Small vessel myography Vascular reactivity Smooth muscle pharmacology Concentration-response Teaching laboratories Safety pharmacology Skeletal muscle Cardiac tissue

01

Small vessel reactivity

Study contraction, relaxation, endothelial function and pharmacological responses in small arteries using the 620M.

02

Larger vascular rings

Measure functional responses in aorta, carotid artery and other larger ring-mounted vessel preparations.

03

Smooth muscle pharmacology

Evaluate agonist, antagonist and inhibitor responses in trachea, intestine, bladder, uterus, colon and ileum.

04

Concentration-response studies

Generate functional response curves in intact preparations while maintaining controlled physiological conditions.

05

Cardiac and skeletal muscle

Measure force generation and stimulated responses in suitable isolated cardiac and skeletal muscle preparations.

06

Teaching and training

Demonstrate mounting, equilibration, preload, normalization, compound addition, washing and response analysis.

Systems

Compare DMT tissue myograph and organ bath platforms

The systems cover small-vessel wire myography, flexible single-channel organ bath studies and four-channel organ bath workflows.

Small vessel myography

Multi Myograph System – 620M

Four-channel wire myograph for vascular structure and function studies, concentration-response work and parallel isometric measurement of small vessels and larger ring preparations.

Channels 4 independent chambers

Preparations Small arteries and larger tissue rings

Mounting Jaws or pins

Normalization Manual length-tension normalization

Best fit Vascular physiology and pharmacology

View 620M Request quote

Multi-channel organ bath

Organ Bath System – 820MO

Integrated four-channel organ bath for parallel studies of isolated smooth, skeletal and cardiac muscle preparations, larger vascular rings and tissue strips.

Channels 4 independent chambers

Preparations Ring and strip-mounted tissue

Best fit Research, screening and shared laboratories

Priority Parallel throughput and standardized workflow

View 820MO Request quote

Teaching and flexible research

Organ Bath System – 751MT

Compact single-channel system with two heated buffer bottles, semi-automated filling and drainage, and isometric or isotonic measurement options.

Channels 1 chamber

Chamber 10 or 20 mL

Measurement Isometric or isotonic

Best fit Teaching, training and flexible research

View 751MT Request quote

Compact single-channel system

Organ Bath System – 752eT

Integrated single-channel organ bath for physiology, pharmacology, teaching, training, pilot studies and focused research protocols.

Channels 1 integrated chamber

Chamber 20 mL standard, 50 mL optional

Measurement Isometric standard, isotonic optional

Best fit Pilot studies and focused workflows

View 752eT Request quote

Quick comparison

First-pass system selection guide

Use this comparison to narrow the system choice before reviewing product-specific specifications and configuration options.

Selection factor	620M	820MO	751MT	752eT
System type	Four-channel wire myograph	Four-channel organ bath	Flexible single-channel organ bath	Integrated single-channel organ bath
Primary preparation	Small vessels and tissue rings	Larger rings and tissue strips	Ring and strip preparations	Vascular rings and tissue strips
Number of chambers	4	4	1	1
Measurement	Isometric force	Isometric force	Isometric or isotonic	Isometric; isotonic optional
Normalization	Manual vessel normalization	Resting tension or protocol-defined preload	Resting tension or protocol-defined preload	Resting tension or protocol-defined preload
Best fit	Vascular physiology and pharmacology	Parallel organ bath research and screening	Teaching and flexible research	Pilot, teaching and focused research
Main advantage	Low-volume parallel small-vessel studies	Parallel larger-tissue throughput	Buffer and measurement flexibility	Compact essential workflow
Product page	View 620M	View 820MO	View 751MT	View 752eT

How to choose

Select the system from the preparation and endpoint backwards

The most appropriate tissue system is determined by tissue geometry, preparation size, normalization needs, mounting method, expected force, chamber volume and parallel throughput.

Small arteries normally require a wire myograph with low chamber volume and reproducible normalization. Larger tissues normally require organ bath mounting flexibility.

Small vessel or larger tissue Use the 620M for small arteries and normalized vessel studies. Consider an organ bath for larger rings, strips and organ-derived preparations.

Preparation geometry Define whether the sample is a small vessel, vascular ring, smooth muscle strip, skeletal muscle or cardiac preparation.

Mounting method Confirm whether the preparation requires jaws, pins, hooks, clips or another tissue support.

Normalization or preload Determine whether formal vessel normalization or a defined resting tension is central to the laboratory protocol.

Expected force range Estimate the expected response so the force transducer and system range match the tissue.

Chamber volume Consider tissue size, reagent cost, buffer use and the compound addition workflow.

Parallel throughput Decide whether the study requires one preparation at a time or four independent samples measured simultaneously.

Acquisition and stimulation Confirm MyoDAQ or other acquisition, analogue outputs, stimulation, electrodes and accessories before quoting.

Software and support

Complete the isolated tissue workflow

A complete setup may include acquisition software, normalization tools, stimulators, electrodes, tissue holders, installation, training and ongoing technical support.

Data acquisition

Record force responses, add experimental markers and export selected or complete datasets for analysis and reporting.

Explore MyoDAQ

Normalization and stimulation

Use MyoNORM for relevant wire-myograph normalization workflows and compatible stimulators for electrically activated tissues.

Explore MyoNORM

Training and scientific support

Support users with system installation, tissue mounting, normalization, practical workflow training and application resources.

Explore training

Resources

Product pages, videos and technical resources

Review the individual systems and supporting DMT resources when planning an isolated tissue or vascular myography installation.

620

Multi Myograph System – 620M

Review four-channel small-vessel and tissue-ring myography.

→ 820

Organ Bath System – 820MO

Review the four-channel platform for parallel organ bath studies.

→ 751

Organ Bath System – 751MT

Review flexible isometric and isotonic tissue workflows.

→ 752

Organ Bath System – 752eT

Review the compact integrated single-channel platform.

→ DAQ

MyoDAQ Acquisition

Review focused data acquisition for compatible DMT systems.

→ VID

Organ bath videos

Review product and practical organ bath workflow videos.

→ DOC

Protocols and articles

Browse scientific and application-focused DMT resources.

→ TECH

Technical support

Request assistance with setup, operation or system compatibility.

→

Configuration guidance

Need help selecting the right isolated tissue system?

Share the tissue type, preparation dimensions, expected force range, mounting method, normalization requirements, chamber volume, number of parallel preparations, stimulation needs and preferred acquisition setup. DMT can help define the appropriate platform and configuration.

Request a quote Ask DMT for guidance