112PP Pressure Myograph Installation at the University of Arizona
A pressure pulsation myograph installation supporting research into coronary microvascular dysfunction in diabetic cardiomyopathy.
DMT recently installed a 112PP Pressure Pulsation Myograph System in Dr. Liya Yin’s laboratory at the University of Arizona, supporting advanced studies of coronary microvascular health and cardiac function.
Supporting coronary microvascular research
Dr. Yin’s research focuses on coronary microvascular dysfunction in diabetic cardiomyopathy, an important area of cardiovascular science examining how diabetes affects the small vessels that regulate blood flow within the heart.
Understanding these changes can help researchers investigate how impaired microvascular function contributes to cardiac dysfunction and how vascular structure, pressure responses and vessel mechanics change during disease progression.
The 112PP allows researchers to study isolated small vessels under controlled pressure and programmable pulsation while tracking vessel structure and function in real time.
Why the 112PP fits this research
The DMT 112PP is designed for pressure myography studies where pulsation, mechanical stretch and vessel-wall behavior are central to the experimental question. Small isolated vessels can be cannulated and maintained under near-physiological conditions while pressure, diameter and longitudinal force are monitored.
Controlled pressure
Study isolated vessels under stable transmural pressure and evaluate pressure-dependent constriction, dilation and structural responses.
Programmable pulsation
Apply dynamic pressure patterns and pulse rates to investigate cyclic mechanical loading and vascular adaptation.
Live vessel analysis
Use MyoVIEW-compatible imaging to track vessel diameter, lumen dimensions, wall thickness and pressure-related changes during experiments.
Microvascular applications
Support studies of coronary microvascular dysfunction, diabetic cardiomyopathy, myogenic tone, vascular stiffness and endothelial function.
From installation to experimental workflow
A successful installation is about more than placing the instrument in the laboratory. It also establishes the pressure circuit, chamber setup, imaging workflow and system controls needed for consistent small-vessel experiments.
By connecting the 112PP configuration to the laboratory’s research goals, the installation helps the team move toward reliable studies of vascular dynamics under both steady and pulsatile pressure conditions.
Learn more: Pressure Pulsation Myograph System – 112PP
The DMT 112PP supports constant-pressure, pulsatile-pressure and non-pulsatile flow workflows for isolated small-vessel studies, with live vessel tracking and longitudinal force measurement.
Open Pressure Pulsation Myograph System – 112PP ›Advancing vascular research at Arizona
The new system gives Dr. Yin’s team a flexible platform for exploring how diabetes influences coronary microvascular structure and function. These experiments can provide high-resolution insight into vascular dynamics that are difficult to capture using less specialized approaches.
We appreciate the opportunity to support Dr. Yin and her team as they continue advancing research into coronary microvascular dysfunction and diabetic cardiomyopathy.
After the installation
Following installation, researchers can continue using DMT resources including manuals, product videos, practical guides, protocols, software downloads and technical support. These materials help maintain consistent workflows as new users, methods and research questions are introduced.
- Guides and manuals for system setup and routine reference
- Product and how-to videos for pressure myograph workflows
- Protocols and articles for application-specific context
- Technical support for troubleshooting and follow-up questions