The Muscle Strip Myograph System - 820MS represents a state-of-the-art 4-channel myograph system for muscle strips of up to 19 mm in length. The system was originally developed to give the skeletal muscle physiologist a highly sophisticated, easy-to-use, robust, high-throughput muscle myograph. The rectangular design of the chamber, however, gives this system the flexibility to mount larger, longer muscle strips of various organs, including larger segments of smooth muscle.
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»unique tissue clamp system to hold
the mounted tissues» |
The system comes standard with a unique tissue clamp system to hold the mounted tissues. Customised mounting supports can be made upon request.
Each muscle bath unit, made of aluminium, features a rectangular stainless steel chamber. The tissue clamp supports are positioned in the chamber, where one side is attached to the force transducer and the other side to a positioner screw. The positioners allow the accurate setting of preload while sensitive force transducers allow provide measurement of isometric muscle contractions. Force output is available as an unfiltered or filtered analog signal or in digital format via a USB connection.
Each muscle bath unit has individually controlled gas inflow and suction. The system is automatically heated to a given user-programmed set temperature.
Following mounting and equilibration, the length-tension relationships of the muscle can be determined. During the actual experiment, the length of the muscle is kept constant. Compounds can be added directly to the chamber to assess any positive or negative inotropism.
Stimulation electrodes built into the chamber cover (optional) can be used to activate the muscle via field stimulation from the Combined Pulse & Train Stimulator - CS200.
This myograph is well suited for studies involving muscle strip reactivity. Multiple units, especially in combination with the Automatic Buffer Filler System - 625FS, can be conveniently arranged side-by-side, making the 820MS ideal for work requiring high-throughput screening, such as drug testing or for experiments requiring the separation of muscle preparations in individual baths. |
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Supports
The clamp supports have a width of 3 mm. Another possibility is to have the supports as vertical hooks where the muscle strip ends are mounted with suture wire.
Muscle unit
The rectangular chamber allows a maximum segment length of 15 mm and can be used for study of various organs.
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