MUSCLE STRIP MYOGRAPH SYSTEM - GENERAL


DMT Muscle Strip Myograph System - 820MS
 
 
 


Myograph system for striated muscle are the newest additions to the DMT product line and we are actively developing new models. Our goal is to provide researchers with specialized high quality research instruments as well as multi-chamber screening systems. In these systems, pieces of solid muscle are clamped between a mounting support and a force transducer.
             
»pieces of solid muscle are clamped between a mounting support and a force transducer«
       
Striated muscle, in contrast to smooth muscle, typically requires an electrical current or excitation to initiate contraction. It operates at an optimised length or preload. The contractions are often much faster than those found in smooth muscle and require robust force transducers with high fidelity. With analysis, the contractions are often transient and speciality software is needed to analyse the tissue response for both contraction and relaxation parameters.
          
DMT allows for a variety of mounting options in these systems; some based on customer requests. Striated muscle such as cardiac and skeletal muscle can be studied in combination with stimulators that can deliver enough power to excite this tissue in a reproducible way. The 820MS and DMT Current Pulse & Train Generator - CS200 combination is an example of such a system.
        
There is also much research investigating molecular basis of muscle contraction. Measurement of force in a skinned muscle preparation is the preferred method to allow investigator control over the environment and composition of the contractile unit. The measured forces are then much smaller and require special transducers.
            
Because of the varied needs in skeletal muscle research, DMT is currently working with a group of industry partners to develop and widen the number of systems we offer to address the many different areas of striated muscle research. Contact us for further details if you would like to be a part of the development process.
                
 
Basic tissue properties
  • Isometric contraction
  • Length-tension measurements
  • Force transient analysis
  • Muscle mechanics
  • Relaxation-contraction kinetics
Pharmacology & physiology
  • Myosin-actin function modifiers
  • Ion channel modulators
  • Skinned smooth muscle
  • Skinned striated muscle
             
MyoDynamics Muscle Strip Myograph System - 840MD
Pathology & phenotyping

  • Transgenic animal muscle phenotyping
  • Diseased muscle function
  • Acquired or genetic muscle diseases

Further possibilities
  • Combine with electrophysiology, EMG
  • Combine with Ca2+, ATP assay
        
 
 

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