Multi Wire Myograph System - 620M

Wire Myograph with four chambers allows the study of four vessels or tissue rings simultaneously 

Ideal for work requiring a higher throughput such as repetitive concentration-response curves

Jaw and pin mounts facilitate the use of a mix of small or larger ring segments from 30 μm to 450 μm (up to 15 mm using customized pins)

The segments remain viable for >12 hours

Built-in electrical heating, electronic valves for simultaneous rapid removal of buffer, analog output of force

The Multi Wire Myograph System - 620M is the successor to our very popular 610M myograph system. This 4-channel multi myograph system is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in vitro studies of small and large blood vessels, trachea or gut mounted as larger ring preparations (up to 10 mm).

»Centrally located 8 ml stainless steel chamber«

Each individual myograph unit, made of aluminium, has a centrally located 8 ml stainless steel chamber. The tissue supports (jaws or pins) are then positioned in the chamber, where one side is attached to the force transducer and the other side is attached to a micrometer.

Each unit has individually controlled gas inflow and suction. Heating and connections for vacuum and gassing are in the myograph interface, permitting the preparations in all four chambers to be kept under physiological conditions (37°C, and bubbled with a gas mixture of your choice). The interface also houses all the electronics, and micro-processor for calibration, the circuitry for analog outputs, and an USB port for easy updates.

»Ensures reproducibility amongst the segments
and between experiments«

Following mounting and equilibration, passive length-tension relationships for the vessels are determined using a normalization procedure. This ensures reproducibility amongst the segments and between experiments. During actual experiments, the circumference of the vessel is kept constant. Compounds can be added directly to the chamber, and the vessel’s contractility and reactivity are measured under isometric conditions.

»Highly suited for pharmacological investigations
on vessel reactivity«

Vessel mounted on jaws

Vessel mounted on jaws

Vessel mounted on pins

Vessel mounted on pins

This Myograph is highly suited for pharmacological investigations on vessel reactivity. Multiple 620M units, especially in combination with the Automatic Buffer Filler System - 625FS, can be conveniently arranged side-by-side. This makes the 620M an ideal system for work requiring a higher throughput, such as drug screening, concentration responses or experiments where individual testing of vessels in separate baths is necessary.
The Multi Interface is prepared for the DMT Device Enabler allowing Automatic recognition of supported devices by LabChart, use of multiple devices simultaneously, correct units and ranges in LabChart channels and simultaneous recording of data into LabChart alongside a PowerLab. The DMT Device Enabler allows the Multi Wire Myograph - 620M to stream data directly into LabChart without a Powerlab box.
Wojewoda M., Kmiecik K., Ventura-Clapier R., Fortin D., Onopiuk M., Jakubczyk J., Sitek B., Fedorowicz A., Majerczak J., Kaminski K., Chlopicki S., Zoladz JA.
Matthias R. Meyera, Natalie C. Fredettea, Matthias Bartiónb, Eric R. Prossnitza

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